Therapeutic Potential of Dioscorea Extract (DA-9801) in Comparison with Alpha Lipoic Acid on the Peripheral Nerves in Experimental Diabetes

Figure 5

Immunohistochemistry of the sciatic nerve (a) and the area of myelinated nerve fiber (b), the diameter of myelin sheath (c), and the diameter of axon (d) of the experimental groups. Myelinated axonal nerve fibers were less degenerated in the DM+DA-9801 and DM+ALA groups. In addition, the size of nerve fibers with or without myelin sheath was increased in the DM+DA-9801 and DM+ALA groups as compared with the DA-9801-treated DM groups. Data are presented as means ± SD. ^∗𝑃<0.05 versus Normal and ^∗∗𝑃<0.05 versus DM (𝑁=10 in each group). ALA: Alpha lipoic acid and DM: diabetes.

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