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Journal of Diabetes Research
Volume 2013, Article ID 787084, 6 pages
Research Article

The Effect of Food Hardness on the Development of Dental Caries in Alloxan-Induced Diabetic Rats

1Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka 573-0101, Japan
2Laboratory of Clinicopathological Therapeutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiroshima 737-0112, Japan

Received 16 January 2013; Revised 24 April 2013; Accepted 24 April 2013

Academic Editor: Jiro Nakamura

Copyright © 2013 Yutaka Nakahara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have previously shown that dental caries may be produced in diabetic rodent models fed with noncariogenic standard diets; however, many studies usually add large amounts of sugar to the diet to induce dental caries. Moreover, the physical properties of cariogenic diets have been reported as an important factor in the formation of caries. The aim of this study was to clarify the effect of the hardness of non-cariogenic diets on the development of dental caries in diabetic rodents. Seven-week-old female F344 rats were divided into 4 groups: intact rats fed with a standard pelletized or powdered diet and alloxan-induced diabetic rats fed with a standard pelletized or powdered diet. All of the rats were sacrificed at 52 weeks of age for morphological examinations on their dental tissue. Dental caries had developed and extended to all the molars in the diabetic rats that were fed with both the pelletized and powdered diets. Moreover, the lesion was significantly enhanced in the powdered diet group compared to that in the pelletized diet group. In conclusion, food hardness is an important factor influencing the development of dental caries in diabetic rats.