Research Article

The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy

Table 3

Renal functional detection and pathological changes of STZ-induced diabetes and treatments in rats.

Parameters Urinary protein (mg/24 h) Ccr (mL/min·kg) KW/BW (%)Mesangial expansion index

0 w
 Control (n = 7)0.12 ± 0.07*2.90 ± 0.47*0.65 ± 0.09*0.22 ± 0.02*
 STZ (n = 7)0.32 ± 0.08 26.43 ± 7.50 1.30 ± 0.03 0.60 ± 0.02
4 w
 Control (n = 7)0.10 ± 0.04*3.64 ± 1.59* 0.74 ± 0.09* 0.35 ± 0.08*
 STZ + vehicle (n = 7) 0.39 ± 0.02 13.98 ± 2.99 1.40 ± 0.03 0.64 ± 0.04
 STZ + DP (n = 7)0.34 ± 0.02*14.15 ± 3.31 1.26 ± 0.02*0.46 ± 0.05
 STZ + irbesartan (n = 7)0.20 ± 0.03*13.51 ± 3.08 1.25 ± 0.04*0.56 ± 0.02
8 w
 Control (n = 7)0.18 ± 0.02*1.88 ± 0.46*0.65 ± 0.04*0.38 ± 0.08*
 STZ + vehicle (n = 7)0.63 ± 0.04 19.40 ± 6.31 1.39 ± 0.08 0.69 ± 0.01
 STZ + DP (n = 7)0.30 ± 0.01*18.83 ± 2.31 1.22 ± 0.09*0.64 ± 0.05
 STZ + irbesartan (n = 7)0.23 ± 0.04*17.08 ± 7.10 1.28 ± 0.06* 0.62 ± 0.02
12 w
 Control (n = 7)0.13 ± 0.02*1.30 ± 0.48*0.63 ± 0.06*0.40 ± 0.03*
 STZ + vehicle (n = 7)0.74 ± 0.04 15.81 ± 3.77 1.25 ± 0.06 0.79 ± 0.02
 STZ + DP (n = 7)0.27 ± 0.05*15.52 ± 1.50 1.20 ± 0.04*0.68 ± 0.05
 STZ + irbesartan (n = 7)0.26 ± 0.02*14.19 ± 1.66 1.17 ± 0.09*0.74 ± 0.05

P < 0.05 versus STZ + vehicle rats.