Research Article
The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy
Table 3
Renal functional detection and pathological changes of STZ-induced diabetes and treatments in rats.
| Parameters | Urinary protein (mg/24 h) | Ccr (mL/min·kg) | KW/BW (%) | Mesangial expansion index |
| 0 w | | | | | Control (n = 7) | 0.12 ± 0.07* | 2.90 ± 0.47* | 0.65 ± 0.09* | 0.22 ± 0.02* | STZ (n = 7) | 0.32 ± 0.08 | 26.43 ± 7.50 | 1.30 ± 0.03 | 0.60 ± 0.02 | 4 w | | | | | Control (n = 7) | 0.10 ± 0.04* | 3.64 ± 1.59* | 0.74 ± 0.09* | 0.35 ± 0.08* | STZ + vehicle (n = 7) | 0.39 ± 0.02 | 13.98 ± 2.99 | 1.40 ± 0.03 | 0.64 ± 0.04 | STZ + DP (n = 7) | 0.34 ± 0.02* | 14.15 ± 3.31 | 1.26 ± 0.02* | 0.46 ± 0.05 | STZ + irbesartan (n = 7) | 0.20 ± 0.03* | 13.51 ± 3.08 | 1.25 ± 0.04* | 0.56 ± 0.02 | 8 w | | | | | Control (n = 7) | 0.18 ± 0.02* | 1.88 ± 0.46* | 0.65 ± 0.04* | 0.38 ± 0.08* | STZ + vehicle (n = 7) | 0.63 ± 0.04 | 19.40 ± 6.31 | 1.39 ± 0.08 | 0.69 ± 0.01 | STZ + DP (n = 7) | 0.30 ± 0.01* | 18.83 ± 2.31 | 1.22 ± 0.09* | 0.64 ± 0.05 | STZ + irbesartan (n = 7) | 0.23 ± 0.04* | 17.08 ± 7.10 | 1.28 ± 0.06* | 0.62 ± 0.02 | 12 w | | | | | Control (n = 7) | 0.13 ± 0.02* | 1.30 ± 0.48* | 0.63 ± 0.06* | 0.40 ± 0.03* | STZ + vehicle (n = 7) | 0.74 ± 0.04 | 15.81 ± 3.77 | 1.25 ± 0.06 | 0.79 ± 0.02 | STZ + DP (n = 7) | 0.27 ± 0.05* | 15.52 ± 1.50 | 1.20 ± 0.04* | 0.68 ± 0.05 | STZ + irbesartan (n = 7) | 0.26 ± 0.02* | 14.19 ± 1.66 | 1.17 ± 0.09* | 0.74 ± 0.05 |
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P < 0.05 versus STZ + vehicle rats.
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