TY - JOUR
A2 - Yamada, Takahisa
AU - Petzold, Cathleen
AU - Riewaldt, Julia
AU - Watts, Deepika
AU - Sparwasser, Tim
AU - Schallenberg, Sonja
AU - Kretschmer, Karsten
PY - 2013
DA - 2013/03/14
TI - Foxp3+ Regulatory T Cells in Mouse Models of Type 1 Diabetes
SP - 940710
VL - 2013
AB - Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model. In recent years, increasing evidence has implicated CD4+CD25+ regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D. In this paper, we provide an overview of currently available mouse models to study the role of Foxp3+ Treg cells in the control of destructive β cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3+ Treg cells.
SN - 2314-6745
UR - https://doi.org/10.1155/2013/940710
DO - 10.1155/2013/940710
JF - Journal of Diabetes Research
PB - Hindawi Publishing Corporation
KW -
ER -