Foxp3+ Regulatory T Cells in Mouse Models of Type 1 Diabetes
Foxp3+ Treg cell ablation in NOD.Foxp3DTR-GFP mice. (a) Percentage of Foxp3DTR-GFP+ cells among CD4+ T cells in subcutaneous lymph nodes (scLN, top) and pancreatic LNs (pLN, bottom) of NOD.Foxp3DTR-GFP × BDC2.5 mice, which were either left untreated (dashed line) or i.p. injected with DT (0.5 g/mouse on 3 consecutive days). Symbols represent individual mice at indicated time points after the first DT administration. (b) Blood glucose concentrations and (c) diabetes incidence of NOD.Foxp mice (blue triangles: females, ; blue circles: males, ) and NOD.Foxp ×BDC2.5 mice (red triangles: females, ; red circles: males, ), after DT administration, as indicated by the arrowheads.