Variations in Rodent Models of Type 1 Diabetes: Islet Morphology
Figure 9
Lymphocyte infiltration in STZ-treated rats. DA rat pancreas was labeled with insulin antibody and with hematoxylin to reveal nuclear staining. (a) Insulin positive islets showed even staining in control rats. Scale bar = 100 μm for all images. (b) Diabetic normoglycemic (DN) rats showed weak insulin staining in the islet core with atrophied β-cells. (c) There were also islets with scattered hypertrophied β-cells in the DN group. (d) Diabetic hyperglycemic rats showed few hypertrophied β-cells.
