Journal of Diabetes Research

Research Article

Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells

Highly ranked genes in the obesity-control study.

(a) Highly ranked genes with high percentages in obesity-control study


Gene symbol	Official full name	Location	Percentage	References

BCAT1	Branched chain amino-acid transaminase1	Chr12 24,962,958-25,102,393 (−): 12p12.1	63.6%

BMP2K	BMP2 inducible kinase	Chr4 79,697,532-79,833,341 (+): 4q21.21	63.6%

CSRNP2	Cysteine-serine-rich nuclear protein 2	Chr12 51,454,988-51,477,454 (−): 12q13.11-q13.12	63.6%

MYNN	Myoneurin	Chr3 169,490,853-169,507,504 (+): 3q26.2	63.6%	Stewart et al., 2010 [38]

NCKAP5L	NCK-associated protein 5-like	Chr12 50,184,929-50,222,208 (−): 12q13.12	63.6%

SAP30BP	SAP30 binding protein	Chr17 73,663,399-73,704,139 (+): 17q25.1	63.6%	Naukkarinen et al., 2010 [39]

SLC35B4	Solute carrier family 35, member B4	Chr7 133,974,089-134,001,827 (−): 7q33	63.6%	Fox et al., 2007 [16]; Yazbek et al., 2011 [17]

SP1	Sp1 transcription factor	Chr12 53,773,979-53,810,230 (+): 12q13.1	63.6%

(b) Highly ranked genes nearby SNPs conferring susceptibility to obesity


Gene symbol	Official full name	Location	Percentage	References	SNPs (Chr pos; frequencies)

NCKAP5L	NCK-associated protein 5-like	Chr12 50,184,929-50,222,208 (−): 12q13.12	63.6%		rs7132908 (50,263,148; G = 0.73; A = 0.27)

SP1	Sp1 transcription factor	Chr12 53,773,979-53,810,230 (+): 12q13.12	63.6%		rs1443512 (54,342,684; A = 0.31; C = 0.69)

ITGA5	Integrin, alpha 5	Chr12 54,789,045-54,813,050 (−): 12q11-q13	58.3%		rs1443512 (54,342,684; A = 0.31; C = 0.69)

TOMM5	Translocase of outer mitochondrial membrane 5	Chr9 37,588,410-37,592,636 (−): 9p13.2	57.1%		rs16933812 (36,969,205; G = 0.40, T = 0.60)

HSP90AB1	Heat shock protein 90 kDa alpha (cytosolic), class B member 1	Chr6 44,214,849-44,221,614 (+): 6p12	55.6%		rs6905288 (43,758,873; G = 0.38, A = 0.62)

BAP1	BRCA1 associated protein-1	Chr3 52,435,024-52,444,009 (−): 3p21.31-p21.2	50%		rs6784615 (52,506,426; C = 0.04, T = 0.96)

GRB14	Growth factor receptor-bound protein 14	Chr2 165,349,323-165,478,360 (−): 2q22-q24	50%	Cooney et al., 2004 [18]; Holt et al., 2009. [19]	rs10195252 (165,513,091; T = 0.60, C = 0.40)

Note: Chr pos: chromosome position; frequencies: the allele frequencies in 1000 genomes (http://www.ncbi.nlm.nih.gov/variation/tools/1000genomes/).