Chronic Treatment with Ang-(1-7) Reverses Abnormal Reactivity in the Corpus Cavernosum and Normalizes Diabetes-Induced Changes in the Protein Levels of ACE, ACE2, ROCK1, ROCK2 and Omega-Hydroxylase in a Rat Model of Type 1 Diabetes
Figure 4
The levels of ACE and ACE2 protein expression in corpus cavernosum of nondiabetic (C), diabetic (STZ), and STZ-rats chronically treated either with Ang-(1-7) alone (STZ + Ang-(1-7)) or in combination with A779 (STZ + Ang-(1-7) + A779). Panel (a) is a representative western blot showing the levels of ACE, ACE2, and the protein loading control, β-actin. Panels (b) and (c) are densitometry histograms showing levels of ACE and ACE2 normalized to actin, respectively. ; . Asterisk (*) indicates significantly different () mean values from normal nondiabetic rats (C), whereas hash (#) indicates significantly different mean values () from diabetic rats (STZ).
