Data Mining for Identifying Novel Associations and Temporal Relationships with Charcot Foot
Table 1
Well-known associations with Charcot foot, based on 388 patients with Charcot foot. Although not all associations presented here show a significant temporal relationship with Charcot foot, those that do preceded the diagnosis of Charcot foot.
Disease category
ICD-9 code
ICD-9 description
Number (%) with both disorders
Association odds ratio
Association value
Temporal value
Endocrine, nutritional and metabolic diseases, and immunity disorders
250.00*
Type 2 diabetes mellitus
243 (62.6)
55.4
<5 ×
278.00
Obesity
52 (13.4)
11.7
Nervous system
356.9
Peripheral neuropathy
161 (41.5)
101.2
<5 ×
Blood and blood-forming organs
280.0
Anemia due to chronic blood loss
16 (4.1)
9.9
0.80
285.9
Anemia, not otherwise specified
98 (25.3)
14.9
0.085
285.29
Anemia of other chronic diseases
10 (2.6)
43.1
1
280.9
Iron deficiency anemia
32 (8.2)
14.5
0.60
Skin and subcutaneous tissue
682.6
Cellulitis/abscess of leg
87 (22.4)
41.9
<5 ×
682.7
Cellulitis/abscess of foot
98 (25.3)
133.8
<5 ×
Genitourinary system
593.9
Renal & ureteral disorder, not otherwise specified
119 (30.7)
20.9
<5 ×
585
Chronic kidney disease
64 (16.5)
29.4
Musculoskeletal system and connective tissue
714.0
Rheumatoid arthritis
37 (9.5)
13.5
733.00
Osteoporosis
44 (11.3)
12.1
0.29
733.90
Bone/cartilage disorder, not otherwise specified
233 (60.1)
26.0
<5 ×
Injury and poisoning
996.81
Complication of kidney transplant
44 (11.3)
43.3
<5 ×
3.9 × 10−4
External causes of injury and supplemental classification
V42.0
Kidney transplant
50 (12.9)
42.1
<5 ×
This table only lists ICD-9 code 250.00, not the other diabetes codes that also appeared in this cohort of patients.