Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors

Figure 1

GSEA plot. The analysis was performed against the KEGG database for differential enriched pathways between hyperglycemic and normoglycemic islets. Enrichment plots for the downregulated pathways are shown in graphs (a) and (b) and upregulated pathways are shown in graphs (b) and (c). The -axis represents the value of the ranking metric; the -axis represents the rank for all genes. Bottom: plot of the ranked list of all genes. Top: the enrichment score for the gene set as the analysis walks along the ranked list. The score at the peak of the plot is the enrichment score (ES) for this gene set and those genes appearing before or at the peak are defined as core enrichment genes in this gene set. Lower levels of expression are represented in shades of blue and higher expression is represented in red.

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