Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors

Table 2

List of down- and upregulated pathways in hyperglycemic donors.

	Size	NES	NOM value	FDR value
Downregulated KEGG pathways
KEGG_TYPE_II_DIABETES_MELLITUS	45	−1,898	0	0,077
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG	24	−1,812	0	0,108
KEGG_OOCYTE_MEIOSIS	108	−1,543	0,02	0,485
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	83	−1,453	0,04	0,70
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	38	−1,583	0,05	0,610
Upregulated KEGG pathways
KEGG_PROTEASOME	44	2,026	0,005	0,030
KEGG_SPLICEOSOME	125	1,898	0,01	0,075
KEGG_DNA_REPLICATION	36	1,621	0,04	0,821
KEGG_PRIMARY_IMMUNODEFICIENCY	35	1,604	0,02	0,71
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	251	1,593	0,003	0,619
KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	16	1,529	0,03	0,614

Ranking of the genes set was done using GSEA 2.0.13. NES: normalized enrichment score; NOM: nominal; FDR: false discovery rate.