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Journal of Diabetes Research
Volume 2014, Article ID 250620, 7 pages
Research Article

Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis

1Department of Health and Nutrition, Faculty of Human Life Studies, University of Niigata Prefecture, Niigata, Japan
2Department of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, Japan
3Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
4Department of Health Management Center, Mito Kyodo General Hospital, Ibaraki, Japan
5Department of Clinical Trial, Design & Management, Translational Research Center, Kyoto University Hospital, Kyoto, Japan

Received 13 January 2014; Revised 24 April 2014; Accepted 24 April 2014; Published 8 May 2014

Academic Editor: Norman Cameron

Copyright © 2014 Chika Horikawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To assess the association between Helicobacter pylori (HP) infection and glycemic control in patients with diabetes through a meta-analytic approach. Research Design and Methods. Electronic literature searches were conducted for cross-sectional studies that examined the hemoglobin A1c (A1C) level by whether patients with diabetes were or were not carriers of HP. Mean differences in A1C between groups with and without HP infection were pooled with a random-effects model. Results. Thirteen eligible studies were included in this meta-analysis. Overall, the HP carriers did not have significantly higher A1C levels compared with HP noncarriers (mean difference (95% CI), 0.19% (−0.18 to 0.46), ). When the analysis was limited to studies targeting patients with type 1 diabetes, there was also no significant difference in A1C (0.69% (−0.31 to 1.68), ). Conclusions. There was insufficient evidence that HP infection worsened glycemic control in patients with diabetes.