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Journal of Diabetes Research
Volume 2014, Article ID 278063, 6 pages
http://dx.doi.org/10.1155/2014/278063
Research Article

Lipoprotein-Associated Phospholipase A2 Mass Level Is Increased in Elderly Subjects with Type 2 Diabetes Mellitus

13rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic
21st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic
3Department of Immunology and Alergology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic
4Department of Cardiosurgery, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic

Received 23 December 2013; Revised 22 February 2014; Accepted 10 March 2014; Published 10 April 2014

Academic Editor: Belma Turan

Copyright © 2014 J. Fortunato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA2 mass between them. Methods. 44 patients aged years with symptomatic severe aortic valve stenosis underwent TAVI ( ) or BA ( ). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA2 mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure. Results. Lp-PLA2 mass was significantly elevated in this population (  ng/mL before TAVI;  ng/mL before BA) and further increased after TAVI (  ng/mL, ) or BA (  ng/mL, ). Lp-PLA2 mass was significantly increased on the diabetic group before these interventions. Conclusion. Lp-PLA2 may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA2 in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.