Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats
Figure 5
Glomerular and tubulointerstitial alterations in diabetic and control rats. (a) Representative glomerular and tubular structures in the Hematoxylin and Eosin staining. Compared with control rats ((A), (C)), diabetic rats ((B), (D)) showed more severe mesangial expansion and tubular hyaline degeneration. LPD significantly improved mesangial expansion (C) in control rats instead of diabetic rats (D), while it ameliorated the degree of tubular hyaline degeneration in diabetic rats (D) and had no same effects in control rats (C). (b) Quantitative scores of mesangial expansion. (c) Quantitative scores of tubular hyaline degeneration. (d) Alterations of mean glomerular area (MGA) among different groups. LPD reduced MGA in control rats but not in diabetic rats. In (b), (c), and (d), NPD is shown as (□) and LPD is shown as (■). Data in (d) were expressed as mean ± SD. compared with C-NPD group. was compared with D-NPD group.
