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Journal of Diabetes Research
Volume 2014 (2014), Article ID 313718, 12 pages
http://dx.doi.org/10.1155/2014/313718
Review Article

Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective

1The University of Sydney, Faculty of Pharmacy, Sydney, NSW 2006, Australia
2The University of Manitoba, Faculty of Pharmacy, Winnipeg, MB, Canada R3T 2N2
3The University of Sydney, Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, Sydney, NSW 2006, Australia

Received 24 December 2013; Revised 11 March 2014; Accepted 12 March 2014; Published 13 April 2014

Academic Editor: Ramesh K. Goyal

Copyright © 2014 Min Kyong Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. G. Bongartz, B. Braam, C. A. Gaillard et al., “Target organ cross talk in cardiorenal syndrome: animal models,” American Journal of Physiology. Renal Physiology, vol. 303, pp. F1253–F1263, 2012. View at Google Scholar
  2. N. S. Anavekar, J. J. V. McMurray, E. J. Velazquez et al., “Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction,” New England Journal of Medicine, vol. 351, no. 13, pp. 1285–1295, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Damman, G. Navis, A. A. Voors et al., “Worsening renal function and prognosis in heart failure: systematic review and meta-analysis,” Journal of Cardiac Failure, vol. 13, no. 8, pp. 599–608, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. H. L. Hillege, A. R. J. Girbes, P. J. de Kam et al., “Renal function, neurohormonal activation, and survival in patients with chronic heart failure,” Circulation, vol. 102, no. 2, pp. 203–210, 2000. View at Google Scholar · View at Scopus
  5. H. S. Mahapatra, R. Lalmalsawma, N. P. Singh, M. Kumar, and S. C. Tiwari, “Cardiorenal syndrome,” Iranian Journal of Kidney Diseases, vol. 3, no. 2, pp. 61–70, 2009. View at Google Scholar · View at Scopus
  6. J. D. Harnett, R. N. Foley, G. M. Kent, P. E. Barre, D. Murray, and P. S. Parfrey, “Congestive heart failure in dialysis patients: prevalence, incidence, prognosis and risk factors,” Kidney International, vol. 47, no. 3, pp. 884–890, 1995. View at Google Scholar · View at Scopus
  7. F. A. McAlister, J. Ezekowitz, M. Tonelli, and P. W. Armstrong, “Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study,” Circulation, vol. 109, no. 8, pp. 1004–1009, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Ronco, P. McCullough, S. D. Anker et al., “Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative,” European Heart Journal, vol. 31, no. 6, pp. 703–711, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Lazzeri, S. Valente, R. Tarquini, and G. F. Gensini, “Cardiorenal syndrome caused by heart failure with preserved ejection fraction,” International Journal of Nephrology, vol. 2011, Article ID 634903, 7 pages, 2011. View at Publisher · View at Google Scholar
  10. D. E. Forman, J. Butler, Y. Wang et al., “Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure,” Journal of the American College of Cardiology, vol. 43, no. 1, pp. 61–67, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. J. S. Bock and S. S. Gottlieb, “Cardiorenal syndrome: new perspectives,” Circulation, vol. 121, no. 23, pp. 2592–2600, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. C. W. Yancy, M. Lopatin, L. W. Stevenson, T. De Marco, and G. C. Fonarow, “Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database,” Journal of the American College of Cardiology, vol. 47, pp. 76–84, 2006. View at Google Scholar
  13. L. W. Stevenson, A. Nohria, and L. Mielniczuk, “Torrent or torment from the tubules?” Journal of the American College of Cardiology, vol. 45, no. 12, pp. 2004–2007, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. D.-D. Li, J.-H. Chen, Q. Chen et al., “Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db/db mice,” Acta Pharmacologica Sinica, vol. 26, no. 2, pp. 220–222, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M. K. Song, B. D. Roufogalis, and T. H. W. Huang, “Modulation of diabetic retinopathy pathophysiology by natural medicines through PPAR-γ-related pharmacology,” British Journal of Pharmacology, vol. 165, no. 1, pp. 4–19, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Sarraf, A. Masoumi, and R. W. Schrier, “Cardiorenal syndrome in acute decompensated heart failure,” Clinical Journal of the American Society of Nephrology, vol. 4, no. 12, pp. 2013–2026, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Pokhrel, N. Maharjan, B. Dhakal, and R. R. Arora, “Cardiorenal syndrome: a literature review,” Experimental and Clinical Cardiology, vol. 13, no. 4, pp. 165–170, 2008. View at Google Scholar · View at Scopus
  18. C. Ronco, M. Cicoira, and P. A. McCullough, “Cardiorenal syndrome type 1: pathophysiological crosstalk leading to combined heart and kidney dysfunction in the setting of acutely decompensated heart failure,” Journal of the American College of Cardiology, vol. 60, pp. 1031–1042, 2012. View at Google Scholar
  19. C. Ronco and M. Cozzolino, “Mineral metabolism abnormalities and vitamin D receptor activation in cardiorenal syndromes,” Heart Failure Reviews, vol. 17, pp. 211–220, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Hatamizadeh, G. C. Fonarow, M. J. Budoff et al., “Cardiorenal syndrome: pathophysiology and potential targets for clinical management,” Nature Reviews Nephrology, vol. 9, pp. 99–111, 2013. View at Google Scholar
  21. C. Ronco, A. A. House, and M. Haapio, “Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong,” Intensive Care Medicine, vol. 34, no. 5, pp. 957–962, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. M. S. Ahmed, C. F. Wong, and P. Pai, “Cardiorenal syndrome—a new classification and current evidence on its management,” Clinical Nephrology, vol. 74, no. 4, pp. 245–257, 2010. View at Google Scholar · View at Scopus
  23. K. V. Liang, A. W. Williams, E. L. Greene, and M. M. Redfield, “Acute decompensated heart failure and the cardiorenal syndrome,” Critical Care Medicine, vol. 36, no. 1, pp. S75–S88, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Ronco, M. Haapio, A. A. House, N. Anavekar, and R. Bellomo, “Cardiorenal syndrome,” Journal of the American College of Cardiology, vol. 52, no. 19, pp. 1527–1539, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Viswanathan and S. Gilbert, “The cardiorenal syndrome: making the connection,” International Journal of Nephrology, vol. 2011, Article ID 283137, 10 pages, 2011. View at Publisher · View at Google Scholar
  26. M. R. Bristow, “Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology,” Circulation Research, vol. 109, no. 10, pp. 1176–1194, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Laederach and P. Weidmann, “Plasma and urinary catecholamines as related to renal function in man,” Kidney International, vol. 31, no. 1, pp. 107–111, 1987. View at Google Scholar · View at Scopus
  28. I. A. Reid, “Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure,” American Journal of Physiology. Endocrinology and Metabolism, vol. 262, no. 6, pp. E763–E778, 1992. View at Google Scholar · View at Scopus
  29. K. K. Griendling, C. A. Minieri, J. D. Ollerenshaw, and R. W. Alexander, “Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells,” Circulation Research, vol. 74, no. 6, pp. 1141–1148, 1994. View at Google Scholar · View at Scopus
  30. M. Ruiz-Ortega, O. Lorenzo, and J. Egido, “Angiotensin III increases MCP-1 and activates NF-κB and AP-1 in cultured mesangial and mononuclear cells,” Kidney International, vol. 57, no. 6, pp. 2285–2298, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. M. E. Pueyo, W. Gonzalez, A. Nicoletti, F. Savoie, J.-F. Arnal, and J.-B. Michel, “Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-κB activation induced by intracellular oxidative stress,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 3, pp. 645–651, 2000. View at Google Scholar · View at Scopus
  32. G. Remuzzi, N. Perico, M. Macia, and P. Ruggenenti, “The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease,” Kidney International, vol. 68, no. 99, pp. S57–S65, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. A. B. Lewis and M. Chabot, “The effect of treatment with angiotensin-converting enzyme inhibitors on survival of pediatric patients with dilated cardiomyopathy,” Pediatric Cardiology, vol. 14, no. 1, pp. 9–12, 1993. View at Google Scholar · View at Scopus
  34. R. Ferrari, T. Bachetti, L. Agnoletti, L. Comini, and S. Curello, “Endothelial function and dysfunction in heart failure,” European Heart Journal, vol. 19, pp. G41–G47, 1998. View at Google Scholar · View at Scopus
  35. A. J. Kanai, H. C. Strauss, G. A. Truskey, A. L. Crews, S. Grunfeld, and T. Malinski, “Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor,” Circulation Research, vol. 77, no. 2, pp. 284–293, 1995. View at Google Scholar · View at Scopus
  36. M. Ontkean, R. Gay, and B. Greenberg, “Diminished endothelium-derived relaxing factor activity in an experimental model of chronic heart failure,” Circulation Research, vol. 69, no. 4, pp. 1088–1096, 1991. View at Google Scholar · View at Scopus
  37. W. C. Faquin, T. J. Schneider, and M. A. Goldberg, “Effect of inflammatory cytokines on hypoxia-induced erythropoietin production,” Blood, vol. 79, no. 8, pp. 1987–1994, 1992. View at Google Scholar · View at Scopus
  38. M. Katoh, K. Egashira, M. Usui et al., “Cardiac angiotensin II receptors are upregulated by long-term inhibition of nitric oxide synthesis in rats,” Circulation Research, vol. 83, no. 7, pp. 743–751, 1998. View at Google Scholar · View at Scopus
  39. G. M. Felker, K. F. Adams Jr., W. A. Gattis, and C. M. O'Connor, “Anemia as a risk factor and therapeutic target in heart failure,” Journal of the American College of Cardiology, vol. 44, no. 5, pp. 959–966, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Ruiz-Ortega, M. Ruperez, O. Lorenzo et al., “Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney,” Kidney International, vol. 62, no. 82, pp. S12–S22, 2002. View at Google Scholar · View at Scopus
  41. J. Liao, J. A. Keiser, W. E. Scales, S. L. Kunkel, and M. J. Kluger, “Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver,” American Journal of Physiology. Regulatory Integrative and Comparative Physiology, vol. 268, no. 4, pp. R896–R901, 1995. View at Google Scholar · View at Scopus
  42. L. G. Sánchez-Lozada, E. Tapia, R. J. Johnson, B. Rodríguez-Iturbe, and J. Herrera-Acosta, “Glomerular hemodynamic changes associated with arteriolar lesions and tubulointerstitial inflammation,” Kidney International, vol. 64, no. 86, pp. S9–S14, 2003. View at Google Scholar · View at Scopus
  43. S. R. Goldsmith, G. S. Francis, and A. W. Cowley Jr., “Increased plasma arginine vasopressin levels in patients with congestive heart failure,” Journal of the American College of Cardiology, vol. 1, no. 6, pp. 1385–1390, 1983. View at Google Scholar · View at Scopus
  44. T. Mondritzki, P. Kolkhof, H. N. Sabbah et al., “Differentiation of arginine vasopressin antagonistic effects by selective V2 versus dual V2/v1a receptor blockade in a preclinical heart failure model,” American Journal of Therapeutics, vol. 18, no. 1, pp. 31–37, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. H. Funaya, M. Kitakaze, K. Node, T. Minamino, K. Komamura, and M. Hori, “Plasma adenosine levels increase in patients with chronic heart failure,” Circulation, vol. 95, no. 6, pp. 1363–1365, 1997. View at Google Scholar · View at Scopus
  46. V. Vallon, B. Mühlbauer, and H. Osswald, “Adenosine and kidney function,” Physiological Reviews, vol. 86, no. 3, pp. 901–940, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. J. A. Ezekowitz, F. A. McAlister, and P. W. Armstrong, “Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure,” Circulation, vol. 107, no. 2, pp. 223–225, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. T. B. Horwich, G. C. Fonarow, M. A. Hamilton, W. R. MacLellan, and J. Borenstein, “Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure,” Journal of the American College of Cardiology, vol. 39, no. 11, pp. 1780–1786, 2002. View at Publisher · View at Google Scholar · View at Scopus
  49. G. Efstratiadis, D. Konstantinou, I. Chytas, and G. Vergoulas, “Cardio-renal anemia syndrome,” Hippokratia, vol. 12, no. 1, pp. 11–16, 2008. View at Google Scholar · View at Scopus
  50. A. M. Katz, “The cardiomyopathy of overload: an unnatural growth response in the hypertrophied heart,” Annals of Internal Medicine, vol. 121, no. 5, pp. 363–371, 1994. View at Google Scholar · View at Scopus
  51. D. B. Johnson and L. J. Dell'Italia, “Cardiac hypertrophy and failure in hypertension,” Current Opinion in Nephrology and Hypertension, vol. 5, no. 2, pp. 186–191, 1996. View at Publisher · View at Google Scholar · View at Scopus
  52. I. S. Anand, Y. Chandrashekhar, R. Ferrari, P. A. Poole-Wilson, and P. C. Harris, “Pathogenesis of oedema in chronic severe anaemia: studies of body water and sodium, renal function, haemodynamic variables, and plasma hormones,” British Heart Journal, vol. 70, no. 4, pp. 357–362, 1993. View at Google Scholar · View at Scopus
  53. P. E. Sandgren, A. M. Murray, C. A. Herzog, C. A. Solid, D. T. Gilbertson, and R. N. Foley, “Anemia and new-onset congestive heart failure in the general medicare population,” Journal of Cardiac Failure, vol. 11, no. 2, pp. 99–105, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Brownlee, “Biochemistry and molecular cell biology of diabetic complications,” Nature, vol. 414, no. 6865, pp. 813–820, 2001. View at Publisher · View at Google Scholar · View at Scopus
  55. S. M. Grundy, I. J. Benjamin, G. L. Burke et al., “Diabetes and cardiovascular disease: a statement for healthcare professionals from the american heart association,” Circulation, vol. 100, no. 10, pp. 1134–1146, 1999. View at Google Scholar · View at Scopus
  56. H. H. Karnib and F. N. Ziyadeh, “The cardiorenal syndrome in diabetes mellitus,” Diabetes Research and Clinical Practice, vol. 89, no. 3, pp. 201–208, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. A. Arya, S. Aggarwal, and H. N. Yadav, “Pathogenesis of diabetic nephropathy,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 2, no. 4, pp. 24–29, 2010. View at Google Scholar · View at Scopus
  58. A. N. Lasaridis and P. A. Sarafidis, “Diabetic nephropathy and antihypertensive treatment: what are the lessons from clinical trials?” American Journal of Hypertension, vol. 16, no. 8, pp. 689–697, 2003. View at Publisher · View at Google Scholar · View at Scopus
  59. M. E. Molitch, R. A. de Fronzo, M. J. Franz et al., “Nephropathy in diabetes,” Diabetes Care, vol. 27, supplement 1, pp. S79–S83, 2004. View at Google Scholar
  60. X. Yin, Y. Zhang, H. Wu et al., “Protective effects of Astragalus saponin I on early stage of diabetic nephropathy in rats,” Journal of Pharmacological Sciences, vol. 95, no. 2, pp. 256–266, 2004. View at Publisher · View at Google Scholar · View at Scopus
  61. Y. S. Kanwar, J. Wada, L. Sun et al., “Diabetic nephropathy: mechanisms of renal disease progression,” Experimental Biology and Medicine, vol. 233, no. 1, pp. 4–11, 2008. View at Publisher · View at Google Scholar · View at Scopus
  62. C. Maric and J. E. Hall, “Obesity, metabolic syndrome and diabetic nephropathy,” Contributions to Nephrology, vol. 170, pp. 28–35, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. F. N. Ziyadeh, “Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator,” Journal of the American Society of Nephrology, vol. 15, no. 1, pp. S55–S57, 2004. View at Google Scholar · View at Scopus
  64. S. Shafi, N. Tabassum, and F. Ahmed, “Diabetic nephropathy and herbal medicines,” International Journal of Phytopharmacology, vol. 3, pp. 10–17, 2012. View at Google Scholar
  65. L. Yu, N. A. Noble, and W. A. Border, “Therapeutic strategies to halt renal fibrosis,” Current Opinion in Pharmacology, vol. 2, no. 2, pp. 177–181, 2002. View at Publisher · View at Google Scholar · View at Scopus
  66. J. Xu, Z. Li, M. Cao et al., “Synergetic effect of Andrographis paniculata polysaccharide on diabetic nephropathy with andrographolide,” International Journal of Biological Macromolecules, vol. 51, pp. 738–742, 2012. View at Google Scholar
  67. J. B. Buse, H. N. Ginsberg, G. L. Bakris et al., “Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association,” Circulation, vol. 115, no. 1, pp. 114–126, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. J. M. M. Evans, J. Wang, and A. D. Morris, “Comparison of cardiovascular risk between patients with type 2 diabetes and those who had had a myocardial infarction: cross sectional and cohort studies,” British Medical Journal, vol. 324, no. 7343, pp. 939–942, 2002. View at Google Scholar · View at Scopus
  69. T. J. Regan, M. M. Lyons, and S. S. Ahmed, “Evidence for cardiomyopathy in familial diabetes mellitus,” Journal of Clinical Investigation, vol. 60, no. 4, pp. 885–899, 1977. View at Google Scholar · View at Scopus
  70. P. O. Ettinger and T. J. Regan, “Cardiac disease in diabetes,” Postgraduate Medicine, vol. 85, no. 6, pp. 229–232, 1989. View at Google Scholar · View at Scopus
  71. K. S. Spector, “Diabetic cardiomyopathy,” Clinical Cardiology, vol. 21, no. 12, pp. 885–887, 1998. View at Google Scholar · View at Scopus
  72. Y. F. Zhi, J. B. Prins, and T. H. Marwick, “Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications,” Endocrine Reviews, vol. 25, no. 4, pp. 543–567, 2004. View at Publisher · View at Google Scholar · View at Scopus
  73. F. Forcheron, A. Basset, P. Abdallah, P. del Carmine, N. Gadot, and M. Beylot, “Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model - The Zucker diabetic rat,” Cardiovascular Diabetology, vol. 8, article no. 16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. S. Atashak, M. Peeri, M. A. Azarbayjani, S. R. Stannard, and M. M. Haghighi, “Obesity-related cardiovascular risk factors after long- term resistance training and ginger supplementation,” Journal of Sports Science and Medicine, vol. 10, no. 4, pp. 685–691, 2011. View at Google Scholar · View at Scopus
  75. R. Amin, B. Widmer, A. T. Prevost et al., “Risk of microalbuminuria and progression to macroalbuminuria in a cohort with childhood onset type 1 diabetes: prospective observational study,” British Medical Journal, vol. 336, no. 7646, pp. 697–701, 2008. View at Publisher · View at Google Scholar · View at Scopus
  76. P. Hovind, L. Tarnow, P. Rossing et al., “Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: inception cohort study,” British Medical Journal, vol. 328, no. 7448, pp. 1105–1108, 2004. View at Google Scholar · View at Scopus
  77. H. L. Hillege, V. Fidler, G. F. H. Diercks et al., “Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population,” Circulation, vol. 106, no. 14, pp. 1777–1782, 2002. View at Publisher · View at Google Scholar · View at Scopus
  78. P. Rossing, P. Hougaard, K. Borch-Johnsen, and H.-H. Parving, “Predictors of mortality in insulin dependent diabetes; 10 year observational follow up study,” British Medical Journal, vol. 313, no. 7060, pp. 779–784, 1996. View at Google Scholar · View at Scopus
  79. S. F. Dinneen and H. C. Gerstein, “The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus: a systematic overview of the literature,” Archives of Internal Medicine, vol. 157, no. 13, pp. 1413–1418, 1997. View at Google Scholar · View at Scopus
  80. S. Nodari and A. Palazzuoli, “Current treatment in acute and chronic cardio-renal syndrome,” Heart Failure Reviews, vol. 16, no. 6, pp. 583–594, 2011. View at Publisher · View at Google Scholar · View at Scopus
  81. Z. A. Mahmood, M. Sualeh, S. B. Z. Mahmood, and M. A. Karim, “Herbal treatment for cardiovascular disease the evidence based therapy,” Pakistan Journal of Pharmaceutical Sciences, vol. 23, no. 1, pp. 119–124, 2010. View at Google Scholar · View at Scopus
  82. S. Mohana Lakshmi, T. Usha Kiran Reddy, and K. Sandhya Rani, “A review on medicinal plants for nephroprotective activity,” Asian Journal of Pharmaceutical and Clinical Research, vol. 5, pp. 8–14, 2012. View at Google Scholar
  83. C. T. Musabayane, “The effects of medicinal plants on renal function and blood pressure in diabetes mellitus,” Cardiovascular Journal of Africa, vol. 23, pp. 462–468, 2012. View at Google Scholar
  84. H.-Y. Chen, J.-H. Wang, M. Geng et al., “Protective effect of extract of Apocynum venetum on kidneys of streptozotocin-induced diabetic rats,” Yaoxue Xuebao, vol. 45, no. 1, pp. 26–30, 2010. View at Google Scholar · View at Scopus
  85. K. Irie, T. Sato, I. Tanaka, J.-I. Nakajima, M. Kawaguchi, and T. Himi, “Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium,” Journal of Natural Medicines, vol. 63, no. 2, pp. 111–116, 2009. View at Publisher · View at Google Scholar · View at Scopus
  86. J. Zhang, X. Xie, C. Li, and P. Fu, “Systematic review of the renal protective effect of Astragalus membranaceus (root) on diabetic nephropathy in animal models,” Journal of Ethnopharmacology, vol. 126, no. 2, pp. 189–196, 2009. View at Publisher · View at Google Scholar · View at Scopus
  87. J. Y. Zhou, Y. Fan, J. L. Kong, D. Z. Wu, and Z. B. Hu, “Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats,” China Journal of Chinese Materia Medica, vol. 25, no. 5, pp. 300–302, 2000. View at Google Scholar · View at Scopus
  88. H.-W. Zhu, Z.-F. Shi, and Y.-Y. Chen, “Effect of extract of ginkgo bilboa leaf on early diabetic nephropathy,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 25, no. 10, pp. 889–891, 2005. View at Google Scholar · View at Scopus
  89. J. Lu and H. He, “Clinical observation of Gingko biloba extract injection in treating early diabetic nephropathy,” Chinese Journal of Integrative Medicine, vol. 11, no. 3, pp. 226–228, 2005. View at Google Scholar · View at Scopus
  90. X.-S. Li, W.-Y. Zheng, S.-X. Lou, X.-W. Lu, and S.-H. Ye, “Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy,” Chinese Journal of Integrative Medicine, vol. 15, no. 1, pp. 26–29, 2009. View at Publisher · View at Google Scholar · View at Scopus
  91. X.-S. Li, X.-J. Fu, and X.-J. Lang, “Effect of extract of Gingko biloba on soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 in patients with early diabetic nephropathy,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 27, no. 5, pp. 412–414, 2007. View at Google Scholar · View at Scopus
  92. W. Zhou, H. Chai, P. H. Lin, A. B. Lumsden, Q. Yao, and C. Chen, “Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases,” Cardiovascular Drug Reviews, vol. 22, no. 4, pp. 309–319, 2004. View at Google Scholar · View at Scopus
  93. S.-H. Lee, Y.-S. Kim, S.-J. Lee, and B.-C. Lee, “The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy,” Journal of Ethnopharmacology, vol. 137, no. 3, pp. 1409–1414, 2011. View at Publisher · View at Google Scholar · View at Scopus
  94. D. de Zeeuw, R. Agarwal, M. Amdahl et al., “Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial,” The Lancet, vol. 376, no. 9752, pp. 1543–1551, 2010. View at Publisher · View at Google Scholar · View at Scopus
  95. W. Buchwald, P. L. Mikolajczak, A. Krajewska-Patan et al., “Involvement of the different extracts from roots of Salvia miltiorrhiza bunge on acute hypobaric hypoxia-induced cardiovascular effects in rats—preliminary report,” Polish Journal of Veterinary Science, vol. 15, pp. 693–701, 2012. View at Google Scholar
  96. C. M. Li, X. L. Dong, X. D. Fan et al., “Aqueous extract of danshen (Salvia miltiorrhiza Bunge) protects ovariectomized rats fed with high-fat diet from endothelial dysfunction,” Menopause, vol. 20, pp. 100–109, 2013. View at Google Scholar
  97. J.-S. Zhu, G. M. Halpern, and K. Jones, “The scientific rediscovery of an ancient Chinese herbal medicine: cordyceps sinensis part I,” Journal of Alternative and Complementary Medicine, vol. 4, no. 3, pp. 289–303, 1998. View at Google Scholar · View at Scopus
  98. L.-Q. Song, Y. Si-Ming, M. Xiao-Peng, and J. Li-Xia, “The protective effects of Cordyceps sinensis extract on extracellular matrix accumulation of glomerular sclerosis in rats,” African Journal of Pharmacy and Pharmacology, vol. 4, no. 7, pp. 471–478, 2010. View at Google Scholar · View at Scopus
  99. X. F. Yan, Z. M. Zhang, H. Y. Yao et al., “Cardiovascular protection and antioxidant activity of the extracts from the mycelia of cordyceps sinensis act partially via adenosine receptors,” Phytotherapy Research, vol. 27, no. 11, pp. 1597–1604, 2013. View at Google Scholar
  100. W. Xue, J. Lei, X. Li, and R. Zhang, “Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity,” Nutrition Research, vol. 31, no. 7, pp. 555–562, 2011. View at Publisher · View at Google Scholar · View at Scopus
  101. M. G. Friedrich, C. M. Kramer, D. K. Sodickson, S. D. Flamm, P. Buser, and S. Neubauer, “Meeting highlights of the 10th annual scientific sessions of the Society for Cardiovascular Magnetic Resonance and 6th annual meeting of the Working Group for Cardiovascular Magnetic Resonance of the European Society of Cardiology: Rome, Italy, February 2–4, 2007,” Journal of the American College of Cardiology, vol. 50, no. 10, pp. 983–987, 2007. View at Publisher · View at Google Scholar · View at Scopus
  102. U. N. Tripathi and D. Chandra, “The plant extracts of Momordica charantia and Trigonella foenum graecum have antioxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus,” Oxidative Medicine and Cellular Longevity, vol. 2, no. 5, pp. 290–296, 2009. View at Publisher · View at Google Scholar · View at Scopus
  103. B. Raghavan and S. K. Kumari, “Effect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats,” Indian Journal of Physiology and Pharmacology, vol. 50, no. 2, pp. 133–142, 2006. View at Google Scholar · View at Scopus
  104. A. Parveen, R. Babbar, S. Agarwal, A. Kotwani, and M. Fahim, “Mechanistic clues in the cardioprotective effect of terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats,” Cardiovascular Toxicology, vol. 11, no. 1, pp. 48–57, 2011. View at Publisher · View at Google Scholar · View at Scopus
  105. Y. Li, T. H.-W. Huang, and J. Yamahara, “Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity,” Life Sciences, vol. 82, no. 21-22, pp. 1045–1049, 2008. View at Publisher · View at Google Scholar · View at Scopus
  106. Y. Li, L. He, Y. Qi et al., “The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 807451, 12 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  107. Y. Li, G. Peng, Q. Li et al., “Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese zucker rats,” Life Sciences, vol. 75, no. 14, pp. 1735–1746, 2004. View at Publisher · View at Google Scholar · View at Scopus
  108. S. S. Ghosh, H. D. Massey, R. Krieg et al., “Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation,” American Journal of Physiology. Renal Physiology, vol. 296, no. 5, pp. F1146–F1157, 2009. View at Publisher · View at Google Scholar · View at Scopus
  109. W. Yu, J. Wu, F. Cai et al., “Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats,” PLoS ONE, vol. 7, Article ID e52013, 2012. View at Google Scholar
  110. K. S. Jayachandran, M. Khan, K. Selvendiran, S. N. Devaraj, and P. Kuppusamy, “Crataegus oxycantha extract attenuates apoptotic incidence in myocardial ischemia-reperfusion injury by regulating akt and Hif-1 signaling pathways,” Journal of Cardiovascular Pharmacology, vol. 56, no. 5, pp. 526–531, 2010. View at Publisher · View at Google Scholar · View at Scopus
  111. M. A. Lacaille-Dubois, U. Franck, and H. Wagner, “Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants,” Phytomedicine, vol. 8, no. 1, pp. 47–52, 2001. View at Google Scholar · View at Scopus
  112. X. Li, X. Cui, X. Sun, X. Li, Q. Zhu, and W. Li, “Mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats,” Phytotherapy Research, vol. 24, no. 6, pp. 893–899, 2010. View at Publisher · View at Google Scholar · View at Scopus
  113. S. Muruganandan, S. Gupta, M. Kataria, J. Lal, and P. K. Gupta, “Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats,” Toxicology, vol. 176, no. 3, pp. 165–173, 2002. View at Publisher · View at Google Scholar · View at Scopus
  114. F. Turgut, O. Bayrak, F. Catal et al., “Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney tissues of rats,” International Urology and Nephrology, vol. 40, no. 2, pp. 453–460, 2008. View at Publisher · View at Google Scholar · View at Scopus
  115. P. R. Rao and R. K. Viswanath, “Cardioprotective activity of silymarin in ischemia-reperfusion-induced myocardial infarction in albino rats,” Experimental and Clinical Cardiology, vol. 12, no. 4, pp. 179–187, 2007. View at Google Scholar · View at Scopus
  116. S. Sen, S. Chen, B. Feng, Y. Wu, E. Lui, and S. Chakrabarti, “Preventive effects of North American ginseng (Panax quinquefolium) on diabetic nephropathy,” Phytomedicine, vol. 19, no. 6, pp. 494–505, 2012. View at Publisher · View at Google Scholar · View at Scopus
  117. H.-J. Yin, Y. Zhang, and Y.-R. Jiang, “Effect of folium panax quinquefolium saponins on apoptosis of cardiac muscle cells and apoptosis-related gene expression in rats with acute myocardial infarction,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 25, no. 3, pp. 232–235, 2005. View at Google Scholar · View at Scopus
  118. Z. Q. Liu, Q. Z. Li, and G. J. Qin, “Effect of Astragalus injection on platelet function and plasma endothelin in patients with early stage diabetic nephropathy,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 21, no. 4, pp. 274–276, 2001. View at Google Scholar · View at Scopus
  119. M. Li, W. Wang, J. Xue, Y. Gu, and S. Lin, “Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 412–419, 2011. View at Publisher · View at Google Scholar · View at Scopus
  120. L. Zhou, Z. Zuo, and M. S. S. Chow, “Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use,” Journal of Clinical Pharmacology, vol. 45, no. 12, pp. 1345–1359, 2005. View at Publisher · View at Google Scholar · View at Scopus
  121. V. Tripathi, B. Singh, R. Tripathi et al., “Terminalia arjuna its present status,” Oriental Journal of Chemistry, vol. I, pp. 1–16, 1996. View at Google Scholar
  122. A. Shehzad, T. Ha, F. Subhan, and Y. S. Lee, “New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases,” European Journal of Nutrition, vol. 50, no. 3, pp. 151–161, 2011. View at Publisher · View at Google Scholar · View at Scopus
  123. S. K. Verma, V. Jain, and R. Khamesra, “Crataegus oxyacantha—a cardioprotective herb,” Journal of Herbal Medicine and Toxicology, vol. 1, pp. 65–71, 2007. View at Google Scholar
  124. S. Prabhu, M. Jainu, K. E. Sabitha, and C. S. Shyamala Devi, “Effect of mangiferin on mitochondrial energy production in experimentally induced myocardial infarcted rats,” Vascular Pharmacology, vol. 44, no. 6, pp. 519–525, 2006. View at Publisher · View at Google Scholar · View at Scopus
  125. S. C. Pradhan and C. Girish, “Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine,” Indian Journal of Medical Research, vol. 124, pp. 491–504, 2006. View at Google Scholar · View at Scopus
  126. A. S. Attele, J. A. Wu, and C.-S. Yuan, “Ginseng pharmacology: multiple constituents and multiple actions,” Biochemical Pharmacology, vol. 58, no. 11, pp. 1685–1693, 1999. View at Publisher · View at Google Scholar · View at Scopus
  127. A. H. MacLennan, S. P. Myers, and A. W. Taylor, “The continuing use of complementary and alternative medicine in South Australia: costs and beliefs in 2004,” Medical Journal of Australia, vol. 184, no. 1, pp. 27–31, 2006. View at Google Scholar · View at Scopus
  128. J.-P. Cosyns, “Aristolochic acid and “Chinese herbs nephropathy”: a review of the evidence to date,” Drug Safety, vol. 26, no. 1, pp. 33–48, 2003. View at Publisher · View at Google Scholar · View at Scopus
  129. W. Chau, R. Ross, J. Y. Z. Li, T. Y. Yong, S. Klebe, and J. A. Barbara, “Nephropathy associated with use of a Chinese herbal product containing aristolochic acid,” Medical Journal of Australia, vol. 194, no. 7, pp. 367–368, 2011. View at Google Scholar · View at Scopus
  130. F. D. Debelle, J.-L. Vanherweghem, and J. L. Nortier, “Aristolochic acid nephropathy: a worldwide problem,” Kidney International, vol. 74, no. 2, pp. 158–169, 2008. View at Publisher · View at Google Scholar · View at Scopus
  131. K. Wojcikowski, D. W. Johnson, and G. Gobé, “Medicinal herbal extracts—renal friend or foe? part one: the toxicities of medicinal herbs,” Nephrology, vol. 9, no. 5, pp. 313–318, 2004. View at Publisher · View at Google Scholar · View at Scopus
  132. N. M. Davies and J. A. Yanez, “Toxicology and safety of flavonoids,” in Flavonoid Pharmacokinetics: Methods of Analysis Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology, pp. 249–280, John Wiley & Sons, 2013. View at Google Scholar
  133. J. F. E. Mann, H. C. Gerstein, J. Poque, J. Bosch, and S. Yusuf, “Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial,” Annals of Internal Medicine, vol. 134, no. 8, pp. 629–636, 2001. View at Google Scholar · View at Scopus
  134. G. Manjunath, H. Tighiouart, H. Ibrahim et al., “Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community,” Journal of the American College of Cardiology, vol. 41, no. 1, pp. 47–55, 2003. View at Publisher · View at Google Scholar · View at Scopus
  135. M. G. Shlipak, R. Katz, B. Kestenbaum et al., “Rapid decline of kidney function increases cardiovascular risk in the elderly,” Journal of the American Society of Nephrology, vol. 20, no. 12, pp. 2625–2630, 2009. View at Publisher · View at Google Scholar · View at Scopus
  136. W. B. A. Eijkelkamp, P. A. de Graeff, D. J. van Veldhuisen et al., “Effect of first myocardial ischemic event on renal function,” American Journal of Cardiology, vol. 100, no. 1, pp. 7–12, 2007. View at Publisher · View at Google Scholar · View at Scopus
  137. H. L. Hillege, W. H. van Gilst, D. J. Van Veldhuisen et al., “Accelerated decline and prognostic impact of renal function after myocardial infarction and the benefits of ACE inhibition: the CATS randomized trial,” European Heart Journal, vol. 24, no. 5, pp. 412–420, 2003. View at Publisher · View at Google Scholar · View at Scopus
  138. N. H. Mashour, G. I. Lin, and W. H. Frishman, “Herbal medicine for the treatment of cardiovascular disease: clinical considerations,” Archives of Internal Medicine, vol. 158, no. 20, pp. 2225–2234, 1998. View at Publisher · View at Google Scholar · View at Scopus
  139. V. Jha, “Herbal medicines and chronic kidney disease,” Nephrology, vol. 15, no. 2, pp. 10–17, 2010. View at Publisher · View at Google Scholar · View at Scopus