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Journal of Diabetes Research
Volume 2014, Article ID 453940, 6 pages
http://dx.doi.org/10.1155/2014/453940
Research Article

Metformin Rescues the MG63 Osteoblasts against the Effect of High Glucose on Proliferation

1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu 215006, China
2Department of Endocrinology and Metabolism, Zhangjiagang First People’s Hospital, Zhangjiagang, Jiangsu 215600, China

Received 31 December 2013; Revised 2 March 2014; Accepted 26 March 2014; Published 9 April 2014

Academic Editor: Wang Chen

Copyright © 2014 Xinyu Shao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Wongdee and N. Charoenphandhu, “Osteoporosis in diabetes mellitus: possible cellular and molecular mechanisms,” World Journal of Diabetes, vol. 2, no. 3, pp. 41–48, 2011. View at Publisher · View at Google Scholar
  2. N. P. Botushanov and M. M. Orbetzova, “Bone mineral density and fracture risk in patients with type 1 and type 2 diabetes mellitus,” Folia Medica, vol. 51, no. 4, pp. 12–17, 2009. View at Google Scholar · View at Scopus
  3. M. Janghorbani, R. M. van Dam, W. C. Willett, and F. B. Hu, “Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture,” The American Journal of Epidemiology, vol. 166, no. 5, pp. 495–505, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. R. K. Campbell and J. R. White Jr., “More choices than ever before: emerging therapies for type 2 diabetes,” The Diabetes Educator, vol. 34, no. 3, pp. 518–534, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Wang, H. Li, S. G. Chen et al., “The skeletal effects of thiazolidinedione and metformin on insulin-resistant mice,” Journal of Bone and Mineral Metabolism, vol. 30, no. 6, pp. 630–637, 2012. View at Publisher · View at Google Scholar
  6. S. Dacic, I. Kalajzic, D. Visnjic, A. C. Lichtler, and D. W. Rowe, “Col1a1-driven transgenic markers of osteoblast lineage progression,” Journal of Bone and Mineral Research, vol. 16, no. 7, pp. 1228–1236, 2001. View at Google Scholar · View at Scopus
  7. Y. Cao, X. Liu, and H. Xu, “Utility of serum tartrate-resistant acid phosphatase isoform 5b, bone alkaline phosphatase and osteocalcin in osteoporotic fractures in Chinese patients,” Clinical Laboratory, vol. 58, no. 7-8, pp. 845–850, 2012. View at Google Scholar
  8. M. S. Stalvey, K. L. Clines, V. Havasi et al., “Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease,” PLoS ONE, vol. 8, no. 11, Article ID e80098, 2013. View at Google Scholar
  9. S. Y. Lee, K. S. Lee, S. H. Yi, S. H. Kook, and J. C. Lee, “Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-κB pathway and attenuating ROS production,” PLoS ONE, vol. 8, no. 12, Article ID e80873, 2013. View at Google Scholar
  10. L. S. Holliday, H. G. Welgus, C. J. Fliszar, G. M. Veith, J. J. Jeffrey, and S. L. Gluck, “Initiation of osteoclast bone resorption by interstitial collagenase,” The Journal of Biological Chemistry, vol. 272, no. 35, pp. 22053–22058, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Tao, M. L. Zhang, P. C. Ma et al., “Triptolide inhibits proliferation and induces apoptosis of human melanoma A375 cells,” Asian Pacific Journal of Cancer Prevention, vol. 13, no. 4, pp. 1611–1615, 2012. View at Publisher · View at Google Scholar
  12. H. Sun, K. Dai, T. Tang, and X. Zhang, “Regulation of osteoblast differentiation by slit2 in osteoblastic cells,” Cells Tissues Organs, vol. 190, no. 2, pp. 69–80, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Zhen, Y. Chen, and X. Tang, “Metformin reverses the deleterious effects of high glucose on osteoblast function,” Journal of Diabetes and its Complications, vol. 24, no. 5, pp. 334–344, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. S. Lee, Y. S. Kim, S. Y. Lee et al., “AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts,” Bone, vol. 47, no. 5, pp. 926–937, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Mao, M. Yano, N. Kawao, Y. Tamura, K. Okada, and H. Kaji, “Role of matrix metalloproteinase-10 in the BMP-2 inducing osteoblastic differentiation,” Endocrine Journal, vol. 60, no. 12, pp. 1309–1319, 2013. View at Publisher · View at Google Scholar
  16. J. Yang, Q. Zhou, Y. Wang, K. Liu, and J. Zhang, “Effect of high glucose on PKC and MMPs/TIMPs in human mesangial cells,” Zhong Nan Da Xue Xue Bao Yi Xue Ban, vol. 34, no. 5, pp. 425–431, 2009 (Chinese). View at Google Scholar · View at Scopus
  17. N. Stoynev, I. Dimova, B. Rukova et al., “Gene expression in peripheral blood of patients with hypertension and patients with type 2 diabetes,” Journal of Cardiovascular Medicine, 2013. View at Publisher · View at Google Scholar
  18. J. Feng, Z. Shi, and Z. Ye, “Effects of metabolites of the lignans enterolactone and enterodiol on osteoblastic differentiation of MG-63 cells,” Biological and Pharmaceutical Bulletin, vol. 31, no. 6, pp. 1067–1070, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Tan, Y. Ren, J. Wang et al., “Osteoprotegerin and ligand of receptor activator of nuclear factor,” Angle Orthodontist, vol. 79, no. 2, pp. 292–298, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Park, W. C. Ju, J. H. Yeo et al., “Increased OPG/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation,” International Journal of Molecular Medicine, vol. 33, no. 1, pp. 178–184, 2014. View at Publisher · View at Google Scholar
  21. S. K. Mok, W. F. Chen, W. P. Lai et al., “Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells,” The British Journal of Pharmacology, vol. 159, no. 4, pp. 939–949, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. A. García-Hernández, H. Arzate, I. Gil-Chavarría, R. Rojo, and L. Moreno-Fierros, “High glucose concentrations alter the biomineralization process in human osteoblastic cells,” Bone, vol. 50, no. 1, pp. 276–288, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. K. B. Maresova, K. Pavelka, and J. J. Stepan, “Acute effects of glucocorticoids on serum markers of osteoclasts, osteoblasts, and osteocytes,” Calcified Tissue International, vol. 92, no. 4, pp. 354–361, 2013. View at Publisher · View at Google Scholar