The GLP-1 Analogue Exenatide Improves Hepatic and Muscle Insulin Sensitivity in Diabetic Rats: Tracer Studies in the Basal State and during Hyperinsulinemic-Euglycemic Clamp

Figure 4

Glucose and insulin concentration during the hyperinsulinemic-euglycemic clamp steady state. The concentrations of blood glucose during the clamp steady state were similar among the four groups of rats. (a) Plasma insulin concentrations of the rats were dramatically elevated compared with their basal state (). Furthermore, plasma insulin concentrations in the D group rats were significantly higher than those in the C group rats () and in the C + E group rats () under the clamp steady-state conditions (b). , compared with basal. , compared with C group. , compared with C + E group. ^§,   compared with D group.

(a)

(b)