Generating and Reversing Chronic Wounds in Diabetic Mice by Manipulating Wound Redox Parameters

Figure 9

Schematic illustration of our chronic wound development model and how chronicity is reversed. A wound is created in the presence of excessive levels of reactive oxygen species by inhibiting key antioxidant enzyme (IAE) activity. These wounds become chronic and produce wound exudate that contains bacterial biofilms. Reversal of chronicity towards normal healing was achieved by application of antioxidant agents (AOA) α-toc and N-acetyl cysteine (NAC).