Review Article

Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice

Table 1

General phenotype of diabetic eNOS −/− mice.

PhenotypeModels
High-dose STZ Low-dose STZ Akita db/db

Hyperglycemia*
Survival rate (at 5-6 months after diabetes)50% 70–100% 50% ?
Body weight*
Hypertension + + + +
(SBP increases, mm Hg)*23 10–24 26 (at 7 mo) 35–48
Hyperlipidemia*? (−) ? + (Cho)
Reference # [33] [32, 34, 40] [35] [36, 37]

Vs. diabetic wild-type mice; mo, months; Cho, plasma cholesterol; SBP, systolic blood pressure.