Review Article
Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice
Table 1
General phenotype of diabetic eNOS −/− mice.
| Phenotype | Models | High-dose STZ | Low-dose STZ | Akita | db/db |
| Hyperglycemia* | → | → | → | ↓ | Survival rate (at 5-6 months after diabetes) | 50% | 70–100% | 50% | ? | Body weight* | ↓ | → | ↑ | ↑ | Hypertension | + | + | + | + | (SBP increases, mm Hg)* | 23 | 10–24 | 26 (at 7 mo) | 35–48 | Hyperlipidemia* | ? | (−) | ? | + (Cho) | Reference # | [33] | [32, 34, 40] | [35] | [36, 37] |
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Vs. diabetic wild-type mice; mo, months; Cho, plasma cholesterol; SBP, systolic blood pressure.
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