Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice

Table 2

Comparison of renal phenotype in diabetic eNOS −/− mice.

Phenotype	Models
	High-dose STZ; (C57BL/6J)	Low-dose STZ; (C57BL/6J)	Akita (C57BL/6J × 129S6/SvEv F1)	db/db; (C57BLKS/J)
Albuminuria
Vs. DM WT mice	19.2 (fold increase)	1.8–8.7	2.5	5.3–5.7
Vs. non-DM WT mice	43.1	2.0–30	16	34.9–37.5
GFR*	↓↓	↓	↑↑	↓↓
Tubulointerstitial lesion*	++	+	decreased	++
Oxidative stress*	?	→	↓↓	↑↑
Sensitivity to RAS blockade	(−)	(+)	?	(+)
Reference #	[33]	[32, 34, 39, 40]	[35]	[36, 37, 41]

Vs. diabetic wild-type (DM WT) mice.