Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes

Table 4

miRNAs associated with beta-cell failure.

miRNAs	Cells type/models	Expression change	Known functional effect	References
miR-21	Cells cultured with cytokines	Up	Glucose-induced insulin secretion and proapoptotic	[93]
miR-34a and miR-146a, b	Islets of diabetic db/db mice, cells cultured with cytokines or palmitate	Up	Glucose-induced insulin secretion and proapoptotic	[91, 93]
miR-184	Islets of diabetic db/db mice, cells cultured with glucolipotoxic condition	Down	Glucose-induced insulin secretion	[84, 90]
miR-187	Islets of individuals with type 2 diabetes	Up	Glucose-induced insulin secretion	[85]
miR-199a-3p	Islets of diabetic db/db mice	Up	Proapoptotic	[74]
miR-203 and miR-383	Islets of diabetic db/db mice, cells cultured with glucolipotoxic condition	Down	Proapoptotic	[90, 93]
miR-210	Islets of diabetic db/db mice	Down	Proapoptotic	[84]