Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes

Table 5

Global miRNA profiling of MIN6 cells cultured with human native and oxidized LDL with or without HDL. We compared by microarray analysis the expression of 350 miRNAs in MIN6 cells that were incubated with 2 mmol/L of human native (Na LDL) or oxidized LDL (oxLDL) cholesterol plus or minus 1 mmol/L of HDL for 72 hrs.

Microarray	Name	NaLDL	oxLDL	Change (log2)	Expression change	oxLDL	oxLDL + HDL	Change (log2)
NaLDL versus oxLDL	mmu-miR-9	1 622.36	739.3	−1.16	Down	2 417.08	3 407.71	0.46
	mmu-miR-21	6 073.84	15 447.81	1.37	Up	23 042.48	11 193.24	−1.01
	mmu-miR-98	7 909.01	2 817.75	−1.5	Down	12 432.59	16 691.57	0.42
	mmu-miR-192	222.59	514.66	1.02	Up	1 076.26	732.38	−0.51
	mmu-miR-325	1 018.38	462.41	−1.16	Down	1 757.68	2 642.59	0.65
	mmu-miR-342-3p	2 181.11	1 326.71	−0.73	Down	2 483.59	4 337.97	0.79
	mmu-miR-346	904.18	505.43	−0.85	Down	485.7	770.91	0.64
	mmu-miR-374	5 082.44	1 887.82	−1.43	Down	5 022.55	7 143.28	0.54
	Mmu-miR-708	366.85	712.44	0.94	up	825.11	402.52	−1.06
	mmu-miR-801	488.33	915.52	0.85	up	521.23	216.79	−1.29