Altered Expression Profile of Renal 𝜶_1D-Adrenergic Receptor in Diabetes and Its Modulation by PPAR Agonists

Figure 3

mRNA expression of 𝛼_1D-AR in the glomeruli and cortex of normal ZL and diabetic ZD rats at different time points. 𝛼_1D-AR gene was progressively increased in both glomeruli (a) and cortex (b) of ZD rats compared to normal ZL littermates. mRNA fold changes of 𝛼_1D-AR were calculated using 𝛽-actin as an internal control. Values are mean ± SEM. 𝑛=5-6 animals/group. ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus ZL control group.

(a)

(b)