Table 5: Summary of selected clinical trials in which IL-6 level has been measured as a clinical outcome before and after exercise.

NumberSubjectsExercise intensityMeasured parametersResults

18124 insulin resistant obese individualsSix months of moderate intensity exercise plus hypocaloric diet IL-6, leptin, adiponectin, resistin, TNF-α, hsCRP, and insulin sensitivityPlasma leptin and IL-6 decreased. TNF-α tended to decrease. Adiponectin increased in diabetics
18256 obese women and 40 age-matched normal weightOne year of increased physical activity (at least 1 h walk 3 times/wk) plus energy restricted dietProinflammatory cytokines including TNF-α, IL-6, P-selectin, VCAM-1, ICAM-1 plus glucose, and lipid profileProinflammatory cytokines were higher in obese individuals
Weight reduction was associated with decreased levels of IL-6 and TNF-α
18315 athletes participants in an ultradistance foot race246 Km SpartathlonIL-6, CRP, SAA, free plasma DNA, and lipid profileIL-6 (8000 fold), CRP, SAA, and free plasma DNA levels increased at the end of this acute exercise
18449 white obese school aged childrenA combined protocol of energy restriction and increased physical activity for 3 weeksIndexes of obesity, IL-6, leptin, estradiol, systolic and diastolic BP, and HRAll determined parameters decreased significantly during 3-week program
18517 healthy young women (YW) and 8 postmenopausal women (PMW) Five sets of six maximal eccentric actions of the elbow flexorsCK, IL-6, IL-10, TNF-α, and PGE2For YW, IL-6 and IL-10 values increased 72 h after eccentric exercise
18611 endurance athletesTwo experimental trials consisted of 90 min run at 75% of VO2 max IL-6, free Hb, haptoglobin, hepcidin, and iron parametersSerum iron and IL-6 significantly increased after exercise
18760 overweight/obese diabetic patient randomized to exercise or control groups16-week aerobic exercise training consisting of four 45–60 min sessions/week (50–60% of VO2 max)Insulin resistance, plasma levels of resistin, IL-6, FBS, and lipid profileExercise training decreased both plasma IL-6 and IL-18

BP: blood pressure; FBS: fasting blood sugar; Hb: hemoglobin; HR: heart rate; hs-CRP: high sensitivity C reactive protein; ICAM-1: intercellular adhesion molecule-1; PGE2: prostaglandin E2; SAA: serum amyloid A; VCAM-1: vascular cell adhesion molecule.