Decompensation of β-Cells in Diabetes: When Pancreatic β-Cells Are on ICE(R)
Figure 2
Schematic model for function of the passive repressor ICER. (a) Binding of CREB to CRE occurs when CREB is phosphorylated and the level of ICER is low. CREB can either homodimerize or form heterodimers with other activators, thereby activating gene expression. ICER competes with CREB for binding to CRE when it reaches a certain level. In this case, ICER can either (b) heterodimerize with CREB or (c) homodimerize.
