Decompensation of β-Cells in Diabetes: When Pancreatic β-Cells Are on ICE(R)

Figure 3

Target genes regulated by CREB and ICER in pancreatic β-cells. Typically phosphorylation of CREB results from the protein kinase A (PKA) activity. PKA activity is stimulated by the G protein coupled receptor-induced increase of cAMP. Some genes regulated by CREB and consequently ICER are listed in the schema. Sur1: sulfonylurea receptor 1; neurogenic differentiation 1: NeuroD; Irs2: insulin receptor 2; Per1: Period 1; Ib1: islet brain 1; Noc2: no C2 domain protein, Cx36: Connexin 36.