Journal of Diabetes Research / 2014 / Article / Tab 2

Review Article

The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Table 2

Characteristics of all studies assessing the relationship between VEGF and diabetic retinopathy (PDR versus NPDR).

First authorYearCountry/racial decentStudy designCasesa (PDR)Controlsa (NPDR)CasesControls
11b12b22b11b12b22b

−634 G>C (rs2010963)
Awata [25]2002Japan (Asian)Hospital based controls7080243016145115
Uthra [19]2008India (Asian)Population based controls44872117339337
Chun [21]2010Korea (Asian)Hospital based controls145108487324375219

+936 C/T (rs3025039)
Awata [25]2002Japan (Asian)Hospital based controls70804420649274
Uthra [19]2008India (Asian)Population based controls4487359076100
Kim [26]2009Korea (Asian)Population based controls378415193404415

PDR: proliferative diabetic retinopathy; NPDR: nonproliferative diabetic retinopathy.
aSample size.
b11: wild-type homozygote; 12: heterozygote; 22: variant homozygote.

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