Journal of Diabetes Research / 2014 / Article / Tab 3

Review Article

The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Table 3

Meta-analysis of the associations between the VEGF polymorphisms and DR risk (DR versus DWR).

Variables Variant homozygote versus
wild-type homozygote
Heterozygote versus
wild-type homozygote
Dominant modelRecessive modelAdditive model
OR
(95% CI)
(%)Egger’s test OR
(95% CI)
(%)Egger’s test OR
(95% CI)
(%)Egger’s test OR
(95% CI)
(%)Egger’s test OR
(95% CI)
(%)Egger’s test

−634 G>C (rs2010963)
Overall71.07
(0.81–1.40)
0.6117.80.721.06
(0.87–1.29)
0.5417.60.881.04
(0.86–1.24)
0.6730.90.851.05
(0.82–1.33)
0.6900.551.04
(0.92–1.19)
0.4728.50.80
Asian51.06
(0.71–1.58)
0.7540.60.971.04
(0.84–1.30)
0.6839.20.401.07
(0.79–1.44)
0.6650.60.531.04
(0.80–1.36)
0.7100.751.04
(0.85–1.27)
0.6648.30.78
Hospital
based
61.07
(0.81–1.41)
0.6331.50.711.03
(0.84–1.27)
0.7226.70.791.04
(0.86–1.27)
0.6342.20.741.05
(0.82–1.35)
0.6700.581.03
(0.91–1.18)
0.5739.10.71

–2578 C/A (rs699947)
Overall61.47
(0.81–2.67)
0.2059.60.471.31
(0.87–1.96)
0.1970.00.341.33
(0.89–1.99)
0.1572.10.441.17
(0.68–1.99)
0.5658.90.981.24
(0.92–1.66)
0.1472.20.62
Asian41.59
(0.71–3.56)
0.2571.70.771.26
(0.79–2.01)
0.3277.30.731.32
(0.82–2.13))
0.2480.30.691.45
(0.71–2.95)
0.2965.10.801.29
(0.87–1.92)
0.1981.50.54
Hospital
based
61.47
(0.81–2.67)
0.2059.60.471.31
(0.87–1.96)
0.19700.341.33
(0.89–1.99)
0.1572.10.441.17
(0.68–1.99)
0.5658.90.981.24
(0.92–1.66)
0.1472.20.62

+936 C/T (rs3025039)
Overall43.73
(0.76–18.25)
0.1050.70.481.47
(0.59–3.66)
0.4090.80.291.54
(0.62–3.85)
0.3491.20.333.19
(1.20–8.41)
0.01*32.70.531.49
(0.71–3.12)
0.2889.70.34
Asian43.73
(0.76–18.25)
0.1050.70.481.47
(0.59–3.66)
0.4090.80.291.54
(0.62–3.85)
0.3491.20.333.19
(1.20–8.41)
0.01*32.70.531.49
(0.71–3.12)
0.2889.70.34

–460 T/C (rs833061)
Overall32.46
(0.66–9.11)
0.17640.561.50
(0.50–4.51)
0.4692.10.111.57
(0.51–4.89)
0.42930.272.12
(1.12–4.01)
0.02*42.40.661.53
(0.76–3.07)
0.2288.30.25

Number of studies.
: test used to determine the significance of the overall OR.
: inconsistency index; random-effects model was used when test >50%; otherwise, fix-effects model was used.
NA: Not available.
*Significant results.

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