The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
Table 3
Meta-analysis of the associations between the VEGF polymorphisms and DR risk (DR versus DWR).
Variables
Variant homozygote versus wild-type homozygote
Heterozygote versus wild-type homozygote
Dominant model
Recessive model
Additive model
OR (95% CI)
(%)
Egger’s test
OR (95% CI)
(%)
Egger’s test
OR (95% CI)
(%)
Egger’s test
OR (95% CI)
(%)
Egger’s test
OR (95% CI)
(%)
Egger’s test
−634 G>C (rs2010963)
Overall
7
1.07 (0.81–1.40)
0.61
17.8
0.72
1.06 (0.87–1.29)
0.54
17.6
0.88
1.04 (0.86–1.24)
0.67
30.9
0.85
1.05 (0.82–1.33)
0.69
0
0.55
1.04 (0.92–1.19)
0.47
28.5
0.80
Asian
5
1.06 (0.71–1.58)
0.75
40.6
0.97
1.04 (0.84–1.30)
0.68
39.2
0.40
1.07 (0.79–1.44)
0.66
50.6
0.53
1.04 (0.80–1.36)
0.71
0
0.75
1.04 (0.85–1.27)
0.66
48.3
0.78
Hospital based
6
1.07 (0.81–1.41)
0.63
31.5
0.71
1.03 (0.84–1.27)
0.72
26.7
0.79
1.04 (0.86–1.27)
0.63
42.2
0.74
1.05 (0.82–1.35)
0.67
0
0.58
1.03 (0.91–1.18)
0.57
39.1
0.71
–2578 C/A (rs699947)
Overall
6
1.47 (0.81–2.67)
0.20
59.6
0.47
1.31 (0.87–1.96)
0.19
70.0
0.34
1.33 (0.89–1.99)
0.15
72.1
0.44
1.17 (0.68–1.99)
0.56
58.9
0.98
1.24 (0.92–1.66)
0.14
72.2
0.62
Asian
4
1.59 (0.71–3.56)
0.25
71.7
0.77
1.26 (0.79–2.01)
0.32
77.3
0.73
1.32 (0.82–2.13))
0.24
80.3
0.69
1.45 (0.71–2.95)
0.29
65.1
0.80
1.29 (0.87–1.92)
0.19
81.5
0.54
Hospital based
6
1.47 (0.81–2.67)
0.20
59.6
0.47
1.31 (0.87–1.96)
0.19
70
0.34
1.33 (0.89–1.99)
0.15
72.1
0.44
1.17 (0.68–1.99)
0.56
58.9
0.98
1.24 (0.92–1.66)
0.14
72.2
0.62
+936 C/T (rs3025039)
Overall
4
3.73 (0.76–18.25)
0.10
50.7
0.48
1.47 (0.59–3.66)
0.40
90.8
0.29
1.54 (0.62–3.85)
0.34
91.2
0.33
3.19 (1.20–8.41)
0.01*
32.7
0.53
1.49 (0.71–3.12)
0.28
89.7
0.34
Asian
4
3.73 (0.76–18.25)
0.10
50.7
0.48
1.47 (0.59–3.66)
0.40
90.8
0.29
1.54 (0.62–3.85)
0.34
91.2
0.33
3.19 (1.20–8.41)
0.01*
32.7
0.53
1.49 (0.71–3.12)
0.28
89.7
0.34
–460 T/C (rs833061)
Overall
3
2.46 (0.66–9.11)
0.17
64
0.56
1.50 (0.50–4.51)
0.46
92.1
0.11
1.57 (0.51–4.89)
0.42
93
0.27
2.12 (1.12–4.01)
0.02*
42.4
0.66
1.53 (0.76–3.07)
0.22
88.3
0.25
Number of studies. : test used to determine the significance of the overall OR. : inconsistency index; random-effects model was used when test >50%; otherwise, fix-effects model was used. NA: Not available.
*Significant results.
