Journal of Diabetes Research / 2014 / Article / Tab 4

Review Article

The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Table 4

Meta-analysis of the associations between the VEGF polymorphisms and DR risk (PDR versus NPDR).

Variables Variant homozygote versus
wild-type homozygote
Heterozygote versus
wild-type homozygote
Dominant modelRecessive modelAdditive model
OR
(95% CI)
(%)Egger’s test OR
(95% CI)
(%)Egger’s test OR
(95% CI)
(%)Egger’s test OR
(95% CI)
(%)Egger’s test OR
(95% CI)
(%)Egger’s test

−634 G>C (rs2010963)
Overall30.62
(0.36–1.06)
0.0800.630.73
(0.36–1.46)
0.3764.50.520.76
(0.43–1.34)
0.3552.90.511.02
(0.63–1.65)
0.9000.840.91
(0.70–1.17)
0.4700.70

+936 C/T (rs3025039)
Overall30.93
(0.37– 2.33)
0.8927.1NA1.11
(0.70– 1.77)
0.6400.051.1
(0.70– 1.72)
0.6600.190.89
(0.37–2.13)
0.8046.3NA1.04
(0.73–1.5)
0.8000.29

Number of studies.
: test used to determine the significance of the overall OR.
: inconsistency index; random-effects model was used when test <50%; otherwise, fix-effects model was used.
NA: not available.

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