The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Table 4

Meta-analysis of the associations between the VEGF polymorphisms and DR risk (PDR versus NPDR).

Variables	𝑛^a	Variant homozygote versus; wild-type homozygote				Heterozygote versus; wild-type homozygote				Dominant model				Recessive model				Additive model
		OR; (95% CI)	𝑃(𝑧)	𝐼^2 (%)	Egger’s test 𝑃	OR; (95% CI)	𝑃(𝑧)	𝐼^2 (%)	Egger’s test 𝑃	OR; (95% CI)	𝑃(𝑧)	𝐼^2 (%)	Egger’s test 𝑃	OR; (95% CI)	𝑃(𝑧)	𝐼^2 (%)	Egger’s test 𝑃	OR; (95% CI)	𝑃(𝑧)	𝐼^2 (%)	Egger’s test 𝑃
−634 G>C (rs2010963)
Overall	3	0.62; (0.36–1.06)	0.08	0	0.63	0.73; (0.36–1.46)	0.37	64.5	0.52	0.76; (0.43–1.34)	0.35	52.9	0.51	1.02; (0.63–1.65)	0.90	0	0.84	0.91; (0.70–1.17)	0.47	0	0.70
+936 C/T (rs3025039)
Overall	3	0.93; (0.37– 2.33)	0.89	27.1	NA	1.11; (0.70– 1.77)	0.64	0	0.05	1.1; (0.70– 1.72)	0.66	0	0.19	0.89; (0.37–2.13)	0.80	46.3	NA	1.04; (0.73–1.5)	0.80	0	0.29

aNumber of studies.
𝑃(𝑧): 𝑧 test used to determine the significance of the overall OR.
𝐼²: inconsistency index; random-effects model was used when 𝐼² test <50%; otherwise, fix-effects model was used.
NA: not available.