TY - JOUR A2 - Dalle, Stephane AU - Ezanno, Hélène AU - Pawlowski, Valérie AU - Abdelli, Saida AU - Boutry, Raphael AU - Gmyr, Valery AU - Kerr-Conte, Julie AU - Bonny, Christophe AU - Pattou, François AU - Abderrahmani, Amar PY - 2014 DA - 2014/06/16 TI - JNK3 Is Required for the Cytoprotective Effect of Exendin 4 SP - 814854 VL - 2014 AB - Preservation of beta cell against apoptosis is one of the therapeutic benefits of the glucagon-like peptide-1 (GLP1) antidiabetic mimetics for preserving the functional beta cell mass exposed to diabetogenic condition including proinflammatory cytokines. The mitogen activated protein kinase 10 also called c-jun amino-terminal kinase 3 (JNK3) plays a protective role in insulin-secreting cells against death caused by cytokines. In this study, we investigated whether the JNK3 expression is associated with the protective effect elicited by the GLP1 mimetic exendin 4. We found an increase in the abundance of JNK3 in isolated human islets and INS-1E cells cultured with exendin 4. Induction of JNK3 by exendin 4 was associated with an increased survival of INS-1E cells. Silencing of JNK3 prevented the cytoprotective effect of exendin 4 against apoptosis elicited by culture condition and cytokines. These results emphasize the requirement of JNK3 in the antiapoptotic effects of exendin 4. SN - 2314-6745 UR - https://doi.org/10.1155/2014/814854 DO - 10.1155/2014/814854 JF - Journal of Diabetes Research PB - Hindawi Publishing Corporation KW - ER -