Relationship between Autonomic Nervous System Function and Continuous Interstitial Glucose Measurement in Patients with Type 2 Diabetes

Table 4

Correlation analysis between time-domain parameters of HRV, mean interstitial tissue glucose, and indices of glycemic variability.

Variable	Mean interstitial tissue glucose		MAGE		SD of mean glucose		𝑀-value
	𝑟	𝑃	𝑟	𝑃	𝑟	𝑃	𝑟	𝑃
SDRR (t)	−0.29	0.052	−0.06	0.70	−0.23	0.13	−0.28	0.06
SDRR (n)	−0.28	0.058	−0.19	0.20	−0.39	0.007	−0.40	0.006
PNN30 (t)	−0.07	0.64	−0.02	0.87	−0.15	0.32	−0.25	0.09
PNN30 (n)	−0.14	0.36	−0.06	0.72	−0.19	0.22	−0.27	0.07
PNN50 (t)	−0.11	0.47	−0.06	0.72	−0.14	0.36	−0.27	0.07
PNN50 (n)	−0.20	0.19	−0.10	0.49	−0.23	0.12	−0.35	0.02
SDANN (t)	−0.29	0.054	−0.04	0.79	−0.21	0.16	−0.27	0.07
SDANN (n)	−0.25	0.09	−0.18	0.22	−0.38	0.009	−0.37	0.01
RMMSD (t)	0.05	0.75	0.03	0.86	−0.04	0.80	−0.14	0.36
RMSSD (n)	−0.01	0.93	0.02	0.87	−0.08	0.62	−0.18	0.24

Data are adjusted for HbA1c and duration of diabetes.
All variables are log-transformed due to skewness.
(t): Total; (n): night.
Night period: 23:00–06:00
SDRR: Standard deviation of all normal-to-normal RR intervals
PNN30: Number of pairs of adjacent NN intervals differing >30 ms in the entire recording divided by the total number of all NN intervals
PNN50: Number of pairs of adjacent NN intervals differing >50 ms in the entire recording divided by the total number of all NN intervals
SDANN: 5 min, standard deviation of the changes of NN intervals in all 5-minute segments of the entire recording
RMSSD: The square root of the mean of the sum of the squares of differences between adjacent NN intervals.