MG132 Ameliorates Kidney Lesions by Inhibiting the Degradation of Smad7 in Streptozotocin-Induced Diabetic Nephropathy

Table 1

Results of Body Weight, Kidney Weight, and Kidney Weight Index. Body weight was lower in the experimental groups compared with the NC group, whereas it was significantly recovered in the MH and ML groups compared with the DN group. Conversely, kidney weight and kidney weight index were greater in the experimental groups, but decreased upon MG132 treatment. Changes in the MH group were more significant than the ML group.

Group	Amount	BW (g)	KW (g)	IKW (10^−3)
NC group	10	428.60±20.74	3.04±0.26	6.77±0.90
DN group	10	214.40±7.89^▲	5.06±2.13^▲	45.32±1.83^▲
MH group	10	322.60±25.89^▲■*	3.58±2.31^▲●	22.55±2.7^▲●*
ML group	10	271.40±28.17^▲■	3.77±1.43^▲●	27.33±2.97^▲●

^▲𝑃<0.05 versus NC group, ^■𝑃<0.01 versus DN group, ^●𝑃<0.05 versus DN group,^∗𝑃<0.01 versus ML group.