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Journal of Diabetes Research
Volume 2014 (2014), Article ID 972431, 7 pages
http://dx.doi.org/10.1155/2014/972431
Research Article

Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly

1Postgraduate School of Food Sciences and Nutrition, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, Japan
2Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, Japan
3Research Institute for Nutrition Sciences, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, Japan
4Diabetes Center, Myodani Hospital, 2350-2 Aza Nashihara, Myodani-cho, Tarumi-ku, Kobe, Hyogo 655-0852, Japan

Received 10 March 2014; Revised 11 May 2014; Accepted 14 May 2014; Published 27 May 2014

Academic Editor: Aristidis Veves

Copyright © 2014 Eriko Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. Methods. Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension. Results. Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (2 = 0.772). Conclusions. The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension.