Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2014, Article ID 978143, 6 pages
http://dx.doi.org/10.1155/2014/978143
Research Article

Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

1Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey
2Department of Biochemistry, Namik Kemal University, Turkey
3Department of Diabetic Patient Education and Care Policlinic, Gaziosmanpasa Taksim Education and Research Hospital, Turkey

Received 1 November 2014; Revised 8 December 2014; Accepted 9 December 2014; Published 22 December 2014

Academic Editor: Mark A. Yorek

Copyright © 2014 Banu Boyuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Barbacid, “Neurotrophic factors and their receptors,” Current Opinion in Cell Biology, vol. 7, no. 2, pp. 148–155, 1995. View at Publisher · View at Google Scholar · View at Scopus
  2. G. R. Lewin and Y.-A. Barde, “Physiology of the neurotrophins,” Annual Review of Neuroscience, vol. 19, pp. 289–317, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. R. M. Lindsay, S. J. Wiegand, C. A. Altar, and P. S. DiStefano, “Neurotrophic factors: from molecule to man,” Trends in Neurosciences, vol. 17, no. 5, pp. 182–190, 1994. View at Publisher · View at Google Scholar · View at Scopus
  4. M. H. Skup, “BDNF and NT-3 widen the scope of neurotrophin activity: pharmacological implantations,” Acta Neurobiologiae Experimentalis, vol. 54, pp. 81–94, 1994. View at Google Scholar
  5. J. Leibrock, F. Lottspeich, A. Hohn et al., “Molecular cloning and expression of brain-derived neurotrophic factor,” Nature, vol. 341, no. 6238, pp. 149–152, 1989. View at Publisher · View at Google Scholar · View at Scopus
  6. Y.-A. Barde, “The nerve growth factor family,” Cytokine and Growth Factor Reviews, vol. 2, no. 4, pp. 237–248, 1990. View at Google Scholar · View at Scopus
  7. E. J. Huang and L. F. Reichardt, “Neurotrophins: roles in neuronal development and function,” Annual Review of Neuroscience, vol. 24, pp. 677–736, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Yamanaka, Y. Itakura, A. Tsuchida, T. Nakagawa, and M. Taiji, “Brain-derived neurotrophic factor (BDNF) prevents the development of diabetes in prediabetic mice,” Biomedical Research, vol. 29, no. 3, pp. 147–153, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Nakagawa, A. Tsuchida, Y. Itakura et al., “Brain-derived neurotrophic factor (BDNF) regulates glucose metabolism by modulating energy balance in diabetic mice,” Diabetes, vol. 49, pp. 436–444, 2000. View at Publisher · View at Google Scholar
  10. M. Ono, J. Ichihara, T. Nonomura et al., “Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice,” Biochemical and Biophysical Research Communications, vol. 238, no. 2, pp. 633–637, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Rios, F. A. N. Guoping, C. Fekete et al., “Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity,” Molecular Endocrinology, vol. 15, no. 10, pp. 1748–1757, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Fujinami, K. Ohta, H. Obayashi et al., “Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: relationship to glucose metabolism and biomarkers of insulin resistance,” Clinical Biochemistry, vol. 41, no. 10-11, pp. 812–817, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. K. S. Krabbe, A. R. Nielsen, R. Krogh-Madsen et al., “Brain-derived neurotrophic factor (BDNF) and type 2 diabetes,” Diabetologia, vol. 50, no. 2, pp. 431–438, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Manni, V. Nikolova, D. Vyagova, G. N. Chaldakov, and L. Aloe, “Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes,” International Journal of Cardiology, vol. 102, no. 1, pp. 169–171, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Suwa, H. Kishimoto, Y. Nofuji et al., “Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus,” Metabolism: Clinical and Experimental, vol. 55, no. 7, pp. 852–857, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Civelek, D. Konukoglu, F. Erdenen, and H. Uzun, “Serum neurotrophic factor levels in patients with type 2 diabetes mellitus: relationship to metabolic syndrome components,” Clinical Laboratory, vol. 59, no. 3-4, pp. 369–374, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Teillon, G. A. Calderon, and M. Rios, “Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARα and FGF21 in mice with hepatic ablation of brain-derived neurotropic factor,” Journal of Endocrinology, vol. 205, no. 1, pp. 37–47, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Tsuchida, T. Nonomura, T. Nakagawa et al., “Brain-derived neurotrophic factor ameliorates lipid metabolism in diabetic mice,” Diabetes, Obesity and Metabolism, vol. 4, no. 4, pp. 262–269, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Yamanaka, Y. Itakura, A. Tsuchida, T. Nakagawa, H. Noguchi, and M. Taiji, “Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice,” Diabetes, Obesity and Metabolism, vol. 9, no. 6, pp. 879–888, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Taşçi, H. K. Kabul, and A. Aydoǧdu, “Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases,” Anadolu Kardiyoloji Dergisi, vol. 12, no. 8, pp. 684–688, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. W. Duan, Z. Guo, H. Jiang, M. Ware, and M. P. Mattson, “Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor,” Endocrinology, vol. 144, no. 6, pp. 2446–2453, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Kuroda, Y. Yamasaki, M. Matsuhisa et al., “Brain-derived neurotrophic factor ameliorates hepatic insulin resistance in Zucker fatty rats,” Metabolism: Clinical and Experimental, vol. 52, no. 2, pp. 203–208, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Golden, A. Emiliano, S. Maudsley et al., “Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging,” PLoS ONE, vol. 5, Article ID e10099, 2010. View at Publisher · View at Google Scholar
  24. J. R. Tonra, M. Ono, X. Liu et al., “Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice,” Diabetes, vol. 4, pp. 262–269, 2002. View at Google Scholar
  25. S. Bonini, A. Lambiase, F. Angelucci, L. Magrini, L. Manni, and L. Aloe, “Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 20, pp. 10955–10960, 1996. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Dicou, C. Masson, W. Jabbour, and V. Nerriere, “Increased frequency of NGF in sera of rheumatoid arthritis and systemic lupus erythematosus patients,” NeuroReport, vol. 5, no. 3, pp. 321–324, 1993. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Oddiah, P. Anand, S. B. McMahon, and M. Rattray, “Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder,” NeuroReport, vol. 9, no. 7, pp. 1455–1458, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Hahn, A. P. Islamian, H. Renz, and W. A. Nockher, “Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation,” Journal of Allergy and Clinical Immunology, vol. 117, no. 4, pp. 787–794, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. S. J. Shin, H. E. Yoon, S. Chung, Y. G. Kim, and D.-J. Kim, “Plasma brain-derived neurotrophic factor in hemodialysis patients,” International Journal of Medical Sciences, vol. 9, no. 9, pp. 772–777, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Tabakman, S. Lecht, S. Sephanova, H. Arien-Zakay, and P. Lazarovici, “Interactions between the cells of the immune and nervous system: neurotrophins as neuroprotection mediators in CNS injury,” Progress in Brain Research, vol. 146, pp. 387–401, 2004. View at Google Scholar · View at Scopus