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Journal of Diabetes Research
Volume 2015, Article ID 167526, 6 pages
Research Article

Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits

Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain

Received 5 November 2014; Accepted 15 January 2015

Academic Editor: Aziz Ghahary

Copyright © 2015 Raquel Díez-Láiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this experimental study we have investigated whether the inclusion of the dietary fiber Plantago ovata husk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use of Plantago ovata husk-metformin association in diabetic rabbits by determining its effects on glucose and insulin concentrations. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). Two groups (numbers 1 and 4) were used as controls (receiving standard or supplemented chow), two groups (numbers 2 and 5) received metformin orally, and the other two (numbers 3 and 6) were treated orally with metformin and psyllium. Plasma glucose concentrations were lower in groups fed with fiber-supplemented chow whereas insulin levels showed important interindividual variations. Glucose pharmacokinetics parameters showed significant differences in and in relation to fiber intake. Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase in , AUC, and in animals fed with fiber. We conclude that Plantago ovata husk intake can contribute to the oral antihyperglycemic treatment of type 2 diabetes.