Research Article

Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits

Table 2

Pharmacokinetic parameters obtained for insulin after the administration of an oral 3 g glucose load in the 6 groups after study. Group 1: control standard; group 2: oral metformin; group 3: oral metformin with Plantago ovata husk; group 4: control supplemented; group 5: oral metformin with supplemented chow; group 6: oral metformin with Plantago ovata husk with supplemented chow.

Standard chowSupplemented chow
GroupGroup 1Group 2Group 3Group 4Group 5Group 6

(mUI/L)1.424 ± 0.8082.279 ± 1.4393.905 ± 2.1391.995 ± 1.2165.082 ± 2.5521.138 ± 0.643
(min)90.0 ± 32.8670.0 ± 40.9960.0 ± 32.8680.0 ± 30.98100.0 ± 30.9865.0 ± 29.50
AUC (mUI⋅min/L)174.5 ± 60.09282.6 ± 205.6342.7 ± 144.2282.6 ± 178.9687.6 ± 349.5145.7 ± 65.20