Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes
Table 4
Quantitative trait loci analysis of GLP1R gene variations with 75 g OGTT response to the GLP-1 analogue by multiple linear regression analyses using additive genetic models with or without adjustment of co-valuables, including age, sex, BMI, DM duration, and glycemic states at baseline.
Gene variants (genotypes)
75 g OGTT variables
Without adjustment
With adjustment
Coefficient (95% CI)
Coefficient (95% CI)
rs3765467 (CC, CT, TT)
Glucose_0 minutes
−2.969 (−21.346, 15.409)
0.743
3.705 (−17.762, 25.172)
0.724
30 minutes
−1.500 (−40.962, 37.962)
0.938
3.210 (−47.712, 54.132)
0.897
60 minutes
2.250 (−53.419, 57.919)
0.935
5.139 (−66.086, 76.364)
0.883
90 minutes
−15.344 (−69.476, 38.788)
0.566
−19.554 (−89.583, 50.475)
0.569
120 minutes
−31.094 (−80.241, 18.053)
0.206
−38.048 (−100.420, 24.324)
0.220
C-peptide_0 minutes
−0.151 (−1.102, 0.800)
0.747
−0.029 (−1.064, 1.007)
0.955
30 minutes
−0.085 (−1.149, 0.978)
0.871
−0.021 (−1.185, 1.142)
0.970
60 minutes
−0.521 (−1.821, 0.779)
0.419
−0.336 (−1.774, 1.101)
0.633
90 minutes
−0.457 (−2.379, 1.466)
0.630
−0.584 (−2.807, 1.638)
0.592
120 minutes
−1.257 (−3.677, 1.164)
0.297
−1.392 (−4.231, 1.447)
0.321
Insulin_0 minutes
−17.459 (−81.946, 47.027)
0.584
−1.133 (−83.148, 80.882)
0.977
30 minutes
−18.566 (−82.716, 45.585)
0.558
−2.694 (−84.957, 79.569)
0.947
60 minutes
−22.191 (−87.217, 42.835)
0.490
−3.985 (−87.257, 79.287)
0.922
90 minutes
−26.144 (−105.761, 53.474)
0.507
−6.281 (−108.580, 96.019)
0.900
120 minutes
−34.109 (−121.846, 53.627)
0.433
−12.734 (−125.719, 100.251)
0.818
rs761386 (CC, CT, TT)
Glucose_0 minutes
−1.435 (−19.160, 16.290)
0.869
1.141 (−18.552, 20.834)
0.906
30 minutes
12.957 (−24.721, 50.634)
0.704
10.326 (−36.077, 56.729)
0.650
60 minutes
20.174 (−32.875, 73.222)
0.443
10.244 (−54.816, 75.304)
0.748
90 minutes
20.826 (−30.997, 72.650)
0.417
18.288 (−45.775, 82.352)
0.561
120 minutes
23.826 (−24.025, 71.677)
0.316
36.804 (−20.040, 93.649)
0.194
C-peptide_0 minutes
−0.083 (−1.000, 0.834)
0.854
0.044 (−0.904, 0.991)
0.925
30 minutes
0.129 (−0.894, 1.152)
0.798
−0.073 (−1.137, 0.991)
0.889
60 minutes
0.519 (−0.732, 1.770)
0.403
0.159 (−1.162, 1.480)
0.806
90 minutes
0.542 (−1.305, 2.390)
0.553
−0.022 (−2.069, 2.024)
0.982
120 minutes
0.953 (−1.396, 3.302)
0.413
0.375 (−2.276, 3.026)
0.773
Insulin_0 minutes
−27.735 (−89.251, 33.781)
0.364
−25.685 (−99.916, 48.546)
0.481
30 minutes
−21.800 (−83.393, 39.793)
0.474
−22.497 (−97.156, 52.161)
0.539
60 minutes
−17.687 (−80.485, 45.111)
0.569
−18.393 (−94.197, 57.411)
0.620
90 minutes
−20.765 (−97.642, 56.111)
0.584
−21.338 (−114.531, 71.856)
0.640
120 minutes
−21.678 (−106.715, 63.358)
0.606
−24.492 (−127.466, 78.483)
0.627
OGTT: oral glucose tolerance test. DM: diabetes mellitus. BMI: body mass index.
