Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes

Table 5

Genetic variations of GLP1R studied in published experiments.

dbSNP rs# cluster ID	Region	Chromosome positio	Heterozygosity	MAF	Function
rs6923761	Exon 4	39065819	0.121	0.0647	Missense/homozygotes for the major allele associated with increase in GLP-1 response
rs3765467	Exon 5	39066296	0.260	0.1538	Missense/heterozygotes for the minor allele associated with increase in GLP-1 response
rs367543060	Exon 5	39066240	N.D.	N.D.	Missense/reduced GLP-1 response in GLP1R variant

Chromosome position determined by GRCh38 assembly.
MAF: minor allele frequency.
N.D.: not determined.