Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading

Table 2

Percentages (95% CI) of patients with reduced sensation to monofilament and vibration and decreased/absent ankle reflex at baseline and after 4 weeks (Phase 1).

	Baseline	4 weeks	value
	% (95% CI)	% (95% CI)
Monofilament	45.5 (30.5–61.1)	60.6 (44.8–74.9)	0.21
VPT hallux right	66.7 (50.9–80.1)	36.4 (22.5–52.2)	0.01
VPT hallux left	63.6 (47.8–77.5)	39.4 (25.1–55.2)	0.05
Ankle reflex right	69.7 (54.0–82.5)	48.5 (33.3–63.9)	0.07
Ankle reflex left	69.7 (54.0–82.5)	60.6 (44.8–74.9)	0.43

VPT: vibration perception threshold.