Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading

Table 3

Percentages (95% CI) of patients with reduced sensation to monofilament and vibration and decreased/absent ankle reflex at 4 weeks and study end (Phase 2).

	-Lipoic acid treatment	-Lipoic acid withdrawal	value
	% (95% CI)	% (95% CI)
Monofilament
Randomization	62.5% (39.1–82.2)	58.8% (36.4–78.8)
Study end	68.8% (45.2–86.8)	64.7% (42.0–83.4)
value
VPT hallux right
Randomization	18.8% (5.3–41.7)	52.9% (31.1–74.0)
Study end	18.8% (5.3–41.7)	35.3% (16.6–58.0)
value
VPT hallux left
Randomization	31.3% (13.2–54.8)	47.1% (26.0–68.9)
Study end	25.0% (9.0–48.4)	35.3% (16.6–58.0)
value
Ankle reflex right
Randomization	43.8% (22.7–66.7)	52.9% (31.1–74.0)
Study end	25.0% (9.0–48.4)	52.9% (31.1–74.0)
value
Ankle reflex left
Randomization	62.5% (39.1–82.2)	58.8% (36.4–78.8)
Study end	37.5% (17.8–60.9)	41.2 (21.2–63.6)
value

VPT: vibration perception threshold.