Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading

Table 5

Individual analgesics used as rescue medication with number of patients given in brackets.

Week from randomization	-Lipoic acid treatment	-Lipoic acid withdrawal
Week 4	(i) Ibuprofen (1); (ii) Ketorolac (1)	(i) Amitriptyline (1); (ii) Ketorolac (2)
Week 8	(i) Amitriptyline (1); (ii) Ibuprofen (1); (iii) Ketorolac (2)	(i) Amitriptyline (1); (ii) Tramadol (1); (iii) Dextropropoxyphene (1); (iv) Gabapentin (2); (v) Diclofenac (1)
Week 12	(i) Tramadol (1); (ii) Dextropropoxyphene (1); (iii) Ibuprofen (1)	(i) Amitriptyline (2); (ii) Diclofenac plus vitamin B (2); (iii) Meloxicam (2); (iv) Gabapentin (2)
Week 16	(i) Tramadol (1); (ii) Naproxen (1); (iii) Paracetamol (1); (iv) Ibuprofen (1)	(i) Amitriptyline (2); (ii) Diclofenac plus vitamin B (2); (iii) Meloxicam (2); (iv) Gabapentin (2)