Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats

Figure 4

Effect of metformin on the renal tissue PCX protein and mRNA expressions in rats. (a) Immunohistochemical stating for PCX (×400); (b) the PCX IOD levels; (c) renal PCX mRNA level. NC: normal rats; DM: HFD-STZ rats; M1: HFD-STZ + metformin (150 mg/kg per day) treatment rats; M2: HFD-STZ + metformin (300 mg/kg per day) treatment rats; M3: HFD-STZ + metformin (500 mg/kg per day) treatment rats. Data are expressed as mean ± SD. , versus NC group; , versus DM group; , versus M1 group.

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