Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat

Figure 4

Insulin secretion from the pancreatic islets of ZFDM and ZF strains. Insulin secretory responses to glucose alone (11.1 mM) and glucose plus GLP-1 (10 nM) in (a) fa/+ () and (b) fa/fa () rats in ZFDM strain at 7 weeks of age. Insulin secretory responses in (c) fa/+ () and (d) fa/fa () rats in ZFDM strain at 11 weeks of age. Insulin secretory responses in (e) +/+ () and (f) fa/fa () rats in ZF strain at 11 weeks of age. The data are expressed as mean ± SEM. Differences in insulin secretion from the pancreatic islets were assessed using Tukey-Kramer method.

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