Proteases and Protease Inhibitors of Urinary Extracellular Vesicles in Diabetic Nephropathy

Table 1

Proteases array coordinate, features, and changing fold.

Coordinates	Protein name	Uniprot number	Gene name	Vesiclepedia	Isoform specificity	Normo	Micro	Macro
A5, A6	ADAM9	Q13443	ADAM9	√	Ectodomain	−2.16	−2.62	−2.92
A11, A12	Cathepsin A	P10619	CTSA	√	Proform and active	1.46	5.93	4.34
A15, A16	Cathepsin C	P53634	CTSC	√	Proform and active	2.47	2.98	2.50
A17, A18	Cathepsin D	P07339	CTSD	√	Proform and active	4.00	6.62	6.88
B3, B4	Cathepsin E	P14091	CTSE	√^*	Proform and active	−1.11	−1.29	−1.63
B5, B6	Cathepsin L	P07711	CTSL1	√	Proform and active	−1.01	2.95	2.27
B11, B12	Cathepsin X/Z/P	Q9UBR2	CTSZ	√	Proform and active	2.63	8.13	7.19
B13, B14	DPPIV/CD26	P27487	DPP4	√	Ectodomain	−1.84	−1.41	1.00
B15, B16	Kallikrein 3/PSA	P07288	KLK3	√	Proform and active	−2.13	1.91	1.68
C3, C4	Kallikrein 6	Q92876	KLK6	√	Proform and active	1.63	1.34	−1.35
C7, C8	Kallikrein 10	O43240	KLK10	√^‡	Proform and active	1.87	1.93	1.90
C11, C12	Kallikrein 13	Q9UKR3	KLK13	X	Proform and active	4.70	4.38	2.44
C15, C16	MMP-2	P08253	MMP2	√	Proform and active	−1.36	−1.50	−1.52
D7, D8	MMP-9	P14780	MMP9	√	Proform and active	6.40	1.83	−1.02
D13, D14	Neprilysin/CD10	P08473	MME	√	Ectodomain	−1.89	−1.30	−1.37
E3, E4	Proteinase 3	P24158	PRTN3	√	Active	4.15	5.20	1.96

Reported in vesiclepedia database in mouse and rat species.
^‡Reported in vesiclepedia database as mRNA.