Association of 2184AG Polymorphism in the RAGE Gene with Diabetic Nephropathy in Chinese Patients with Type 2 Diabetes
Table 2
Clinical and laboratory characteristics of patients with type 2 diabetes classified according to their 2184A/G genotypes.
AA
AG + GG
719
149
—
Sex (male/female)
379/340
86/63
0.265
Age (years)
61.1 ± 11.3
61.3 ± 11.8
0.569
Age at diagnosis of diabetes (years)
52.6 ± 12.5
52.6 ± 12.1
0.894
Known duration of diabetes (years)
9.1 (4.0–13.2)
9.0 (3.9–14.1)
0.247
Smoking (%)
87 (12.1)
18 (12.1)
0.995
Body mass index (kg/m2)
23.8 ± 3.5
23.2 ± 3.7
0.084
Hypertension (%)
308 (42.8)
61 (40.9)
0.670
Systolic blood pressure (mmHg)
136.7 ± 16.8
133.2 ± 15.3
0.122
Diastolic blood pressure (mmHg)
81.5 ± 11.6
80.8 ± 10.5
0.216
HbA1c (%)
8.79 ± 2.27
8.66 ± 2.31
0.108
Fasting blood glucose (mmol/L)
8.52 ± 3.05
8.59 ± 3.86
0.769
Total cholesterol (mmol/L)
4.52 ± 1.37
4.39 ± 1.32
0.099
Triglycerides (mmol/L)
1.40 (0.88–2.32)
1.37 (0.83–2.17)
0.113
LDL-cholesterol (mmol/L)
3.58 ± 0.84
3.41 ± 0.79
0.091
HDL-cholesterol (mmol/L)
1.12 (0.80–1.25)
1.14 (0.81–1.28)
0.236
Serum creatinine (μmol/l)
70.0 (46.0–98.6)
56.6 (41.3–83.5)
0.031
eGFR (mL⋅min−1⋅1.73 m−2)
109 (86.5–137.4)
37.6 (23.8–51.7)
<0.001
AER (mg/24 h)
46.4 (9.8–127.5)
31.2 (6.9–110.4)
0.013
Retinopathy (%)
291 (40.5)
53 (35.6)
0.266
Hypoglycemic treatments
OHA (%)
232 (32.3)
54 (36.2)
0.575
Insulin (%)
249 (34.6)
46 (30.9)
Insulin + OHA (%)
238 (33.1)
49 (32.9)
Data are means ± SD, medians (interquartile range), or (%). values were obtained by an unpaired Student's -test analysis or test, as appropriate. OHA, oral hyperglycemic agent.
