Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15

Figure 6

Schematic representation of the effects of hyperglycaemia and AGEs on GIP responsiveness in the pancreatic beta cell line HIT-T15. Chronic hyperglycemia leads to formation and accumulation of AGEs; therefore the diabetic milieu may be represented as a hyper glycemic environment (HG) reached in AGEs (GS). Together, HG and GS contribute to damage pancreatic beta cell function: expression of GIPR is reduced, and its intracellular signaling is altered, leading to a reduced secretory response to GIP and potentially explaining the loss of GIP responsiveness in T2 diabetes.