Importance of Maternal Diabetes on the Chronological Deregulation of the Intrauterine Development: An Experimental Study in Rat

Figure 1

The common craniofacial malformations associated with maternal hyperglycemia. ((a), (a1)) Frontal and sagittal views show hemifacial microsomia with bilateral asymmetry of the left side, malformed facial muscles and bones (xxx), lateral facial cleft (yellow arrow), and bifid nose (bracket). ((b), (b1)) Notice cleft lip-palate (blue arrow) and agnatia. ((c), (c1)) Observe maxillary agenesis. ((d), (d1)) It shows macroglossia. ((a1), (c1), and (d1)) Notice the hypodeveloped eyelids and the nonopen nostrils.