Alteration of Mevalonate Pathway in Proliferated Vascular Smooth Muscle from Diabetic Mice: Possible Role in High-Glucose-Induced Atherogenic Process
Aortic protein expressions of key enzymes by western blot. (a) Representative blots are shown. β-actin was used as a loading control. ((b)–(g)) The densitometric average was normalized to the values obtained from the analysis of β-actin as an internal control. Data expressed as mean ± SEM. versus age-matched control mice; versus age-matched control mice. HMGR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; P-HMGR, phosphor-3-hydroxy-3-methylglutaryl-coenzyme A reductase; FPPS, farnesyl pyrophosphate synthase; SQS, squalene synthase; GGPPS, geranylgeranyl pyrophosphate synthase; FNT-β, farnesyltransferase-β; GGT-1β, geranylgeranyltransferase-1β.