Alteration of Mevalonate Pathway in Proliferated Vascular Smooth Muscle from Diabetic Mice: Possible Role in High-Glucose-Induced Atherogenic Process

Table 1

Glucose and lipid analysis at 0-, 8-, and 16-week diabetic duration in BALB/c mice.

Week	FBG (mM)	TC (mM)	HDL-C (mM)	LDL-C (mM)	TG (mM)
Control mice
0 ()	7.82 ± 0.70	1.82 ± 0.07	0.93 ± 0.06	0.48 ± 0.06	1.31 ± 0.05
8 ()	7.66 ± 0.62	1.88 ± 0.07	0.86 ± 0.07	0.44 ± 0.06	1.30 ± 0.05
16 ()	8.40 ± 0.61	1.90 ± 0.08	0.93 ± 0.06	0.45 ± 0.06	1.25 ± 0.05
Diabetic mice
0 ()	8.20 ± 0.63	1.93 ± 0.09	0.85 ± 0.06	0.47 ± 0.05	1.26 ± 0.06
8 ()	19.54 ± 1.39^#	1.91 ± 0.08	0.84 ± 0.05	0.48 ± 0.07	1.35 ± 0.06
16 ()	21.04 ± 1.42^#	1.96 ± 0.08	0.77 ± 0.06	0.53 ± 0.07	1.40 ± 0.05

Data expressed as mean ± SEM.
versus age-matched control mice.
FBG, fasting blood glucose; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglyceride.