Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptozotocin-Induced Diabetic Rats

Table 2

Expression of E-cadherin, α-SMA, TLR4, NF-κB p65, IL-1β, and MCP-1 in the tubulointerstitial tissues by immunohistochemistry (mean ± SD).

	NC ()	DM ()	TL ()	TM ()	TH ()
E-cadherin	3.21 ± 0.58	0.27 ± 0.16^a	1.01 ± 0.29^a,b	2.46 ± 0.37^a,b,c	2.62 ± 0.41^a,b,c
α-SMA	0.24 ± 0.15	3.19 ± 0.29^a	2.63 ± 0.21^a,b	2.14 ± 0.18^a,b,c	1.57 ± 0.20^a,b,c,d
TLR4	0.19 ± 0.12	2.92 ± 0.17^a	2.24 ± 0.18^a,b	1.73 ± 0.15^a,b,c	1.29 ± 0.14^a,b,c,d
NF-κB	0.35 ± 0.19	4.12 ± 0.21^a	3.81 ± 0.22^a,b	3.09 ± 0.17^a,b,c	1.94 ± 0.19^a,b,c,d
IL-1β	0.31 ± 0.11	3.48 ± 0.24^a	2.89 ± 0.15^a,b	2.19 ± 0.15^a,b,c	1.96 ± 0.17^a,b,c
MCP-1	0.36 ± 0.09	3.07 ± 0.26^a	2.31 ± 0.12^a,b	1.54 ± 0.18^a,b,c	1.15 ± 0.15^a,b,c,d

NC: normal control; DM: diabetic rats without drug treatment; TL: low-dose TGT (1 mg/kg/day); TM: medium-dose TGT (3 mg/kg/day); TH: high-dose TGT (6 mg/kg/day). versus NC group, versus DM group, versus TL group, and versus TM group.